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Protein-coding gene in the species Homo sapiens
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene .[ 5] [ 6] [ 7]
This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI).[ 7]
PIGQ has been shown to interact with PIGH ,[ 5] PIGA [ 5] PIGC .[ 5]
^ a b c GRCh38: Ensembl release 89: ENSG00000007541 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025728 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b c d Watanabe R, Inoue N, Westfall B, Taron CH, Orlean P, Takeda J, Kinoshita T (Mar 1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1" . EMBO J . 17 (4): 877–85. doi :10.1093/emboj/17.4.877 . PMC 1170437 PMID 9463366 . ^ Tiede A, Schubert J, Nischan C, Jensen I, Westfall B, Taron CH, Orlean P, Schmidt RE (Nov 1998). "Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants" . Biochem J . 334 (3): 609–16. doi :10.1042/bj3340609 . PMC 1219730 PMID 9729469 . ^ a b "Entrez Gene: PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q" .
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