PDZK1

PDZK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EEI, 2EEJ, 2VSP, 3TMH, 4Q2P
Identifiers
Aliases	PDZK1, CAP70, CLAMP, NHERF-3, NHERF3, PDZD1, PDZ domain containing 1
External IDs	OMIM: 603831; MGI: 1928901; HomoloGene: 1964; GeneCards: PDZK1; OMA:PDZK1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	145,708,148 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	96,778,242 bp
RNA expression pattern
	Top expressed in
	duodenum; ; right lobe of liver; ; cerebellar cortex; ; cerebellar hemisphere; ; gallbladder; ; human kidney; ; right hemisphere of cerebellum; ; body of pancreas; ; islet of Langerhans; ; testicle;
	Top expressed in
	right kidney; ; human kidney; ; proximal tubule; ; efferent ductule; ; yolk sac; ; seminiferous tubule; ; jejunum; ; spermatid; ; primary oocyte; ; ileum;
	More reference expression data
	n/a
Gene ontology
Molecular function	scavenger receptor binding; protein-containing complex binding; PDZ domain binding; protein binding; transporter activity;
Cellular component	membrane raft; brush border membrane; plasma membrane; extracellular exosome; apical plasma membrane; membrane; microvillus membrane;
Biological process	cell population proliferation; carnitine transport; positive regulation of ion transmembrane transport; regulation of anion transport; positive regulation of protein targeting to membrane; transport; positive regulation of ion transmembrane transporter activity; positive regulation of cation transmembrane transport; xenobiotic detoxification by transmembrane export across the plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	5174
	59020
	ENSG00000174827
	ENSMUSG00000038298
	Q5T2W1
	Q9JIL4
	NM_001201325; NM_001201326; NM_002614
	NM_001146001; NM_021517; NM_001355710
	NP_001188254; NP_001188255; NP_002605; NP_001358288; NP_001358290
	NP_001139473; NP_067492; NP_001342639
	Wikidata
View/Edit Human	View/Edit Mouse

Na(+)/H(+) exchange regulatory cofactor NHE-RF3 is a protein that in humans is encoded by the PDZK1 gene.^[5]^[6]

Interactions

PDZK1 has been shown to interact with:

AKAP10,^[7]
CLCN3,^[8]
Cystic fibrosis transmembrane conductance regulator^[8]^[9]
FARP2,^[7]
PDZK1IP1,^[7]^[10]^[11]
SLC22A12,^[7]
SLC22A4,^[7]
SLC34A3,^[7]
SLK,^[7] and
Sodium-hydrogen antiporter 3 regulator 1.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174827 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038298 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kocher O, Comella N, Tognazzi K, Brown LF (March 1998). "Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains". Lab Invest. 78 (1): 117–25. PMID 9461128.
^ "Entrez Gene: PDZK1 PDZ domain containing 1".
^ ^a ^b ^c ^d ^e ^f ^g ^h Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (November 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
^ ^a ^b Gentzsch M, Cui L, Mengos A, Chang XB, Chen JH, Riordan JR (February 2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins". J. Biol. Chem. 278 (8): 6440–9. doi:10.1074/jbc.M211050200. PMID 12471024.
^ Wang S, Yue H, Derin RB, Guggino WB, Li M (September 2000). "Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity". Cell. 103 (1): 169–79. doi:10.1016/s0092-8674(00)00096-9. PMID 11051556. S2CID 16697781.
^ Pribanic S, Gisler SM, Bacic D, Madjdpour C, Hernando N, Sorribas V, Gantenbein A, Biber J, Murer H (October 2003). "Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells". Am. J. Physiol. Renal Physiol. 285 (4): F784-91. doi:10.1152/ajprenal.00109.2003. PMID 12837682. S2CID 25450845.
^ Silver DL, Wang N, Vogel S (August 2003). "Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels". J. Biol. Chem. 278 (31): 28528–32. doi:10.1074/jbc.M304109200. PMID 12754212.
^ Klopocki E, Schulze H, Strauss G, Ott CE, Hall J, Trotier F, Fleischhauer S, Greenhalgh L, Newbury-Ecob RA, Neumann LM, Habenicht R, König R, Seemanova E, Megarbane A, Ropers HH, Ullmann R, Horn D, Mundlos S (February 2007). "Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129.

White KE, Biber J, Murer H, Econs MJ (1999). "A PDZ domain-containing protein with homology to Diphor-1 maps to human chromosome 1q21". Ann. Hum. Genet. 62 (Pt 4): 287–90. doi:10.1046/j.1469-1809.1998.6240287.x. PMID 9924606.
Kocher O, Comella N, Gilchrist A, Pal R, Tognazzi K, Brown LF, Knoll JH (1999). "PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein". Lab. Invest. 79 (9): 1161–70. PMID 10496535.
Ikemoto M, Arai H, Feng D, Tanaka K, Aoki J, Dohmae N, Takio K, Adachi H, Tsujimoto M, Inoue K (2000). "Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I". Proc. Natl. Acad. Sci. U.S.A. 97 (12): 6538–43. Bibcode:2000PNAS...97.6538I. doi:10.1073/pnas.100114397. PMC 18651. PMID 10829064.
Wang S, Yue H, Derin RB, Guggino WB, Li M (2000). "Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity". Cell. 103 (1): 169–79. doi:10.1016/S0092-8674(00)00096-9. PMID 11051556. S2CID 16697781.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Gisler SM, Stagljar I, Traebert M, Bacic D, Biber J, Murer H (2001). "Interaction of the type IIa Na/Pi cotransporter with PDZ proteins". J. Biol. Chem. 276 (12): 9206–13. doi:10.1074/jbc.M008745200. PMID 11099500.
Silver DL (2002). "A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liver". J. Biol. Chem. 277 (37): 34042–7. doi:10.1074/jbc.M206584200. PMID 12119305.
Sellin L, Huber TB, Gerke P, Quack I, Pavenstädt H, Walz G (2003). "NEPH1 defines a novel family of podocin interacting proteins". FASEB J. 17 (1): 115–7. doi:10.1096/fj.02-0242fje. PMID 12424224. S2CID 17732086.
Gentzsch M, Cui L, Mengos A, Chang XB, Chen JH, Riordan JR (2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins". J. Biol. Chem. 278 (8): 6440–9. doi:10.1074/jbc.M211050200. PMID 12471024.
Hegedüs T, Sessler T, Scott R, Thelin W, Bakos E, Váradi A, Szabó K, Homolya L, Milgram SL, Sarkadi B (2003). "C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins". Biochem. Biophys. Res. Commun. 302 (3): 454–61. doi:10.1016/S0006-291X(03)00196-7. PMID 12615054.
Silver DL, Wang N, Vogel S (2003). "Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels". J. Biol. Chem. 278 (31): 28528–32. doi:10.1074/jbc.M304109200. PMID 12754212.
Pribanic S, Gisler SM, Bacic D, Madjdpour C, Hernando N, Sorribas V, Gantenbein A, Biber J, Murer H (2003). "Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells". Am. J. Physiol. Renal Physiol. 285 (4): F784–91. doi:10.1152/ajprenal.00109.2003. PMID 12837682. S2CID 25450845.
Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (2004). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
Kocher O, Yesilaltay A, Cirovic C, Pal R, Rigotti A, Krieger M (2004). "Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism". J. Biol. Chem. 278 (52): 52820–5. doi:10.1074/jbc.M310482200. PMID 14551195.
Inoue J, Otsuki T, Hirasawa A, Imoto I, Matsuo Y, Shimizu S, Taniwaki M, Inazawa J (2004). "Overexpression of PDZK1 within the 1q12-q22 Amplicon Is Likely To Be Associated with Drug-Resistance Phenotype in Multiple Myeloma". Am. J. Pathol. 165 (1): 71–81. doi:10.1016/S0002-9440(10)63276-2. PMC 1618545. PMID 15215163.
Anzai N, Miyazaki H, Noshiro R, Khamdang S, Chairoungdua A, Shin HJ, Enomoto A, Sakamoto S, Hirata T, Tomita K, Kanai Y, Endou H (2004). "The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus". J. Biol. Chem. 279 (44): 45942–50. doi:10.1074/jbc.M406724200. PMID 15304510.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174827 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038298 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9461128-5] Kocher O, Comella N, Tognazzi K, Brown LF (March 1998). "Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains". Lab Invest. 78 (1): 117–25. PMID 9461128.

[entrez-6] "Entrez Gene: PDZK1 PDZ domain containing 1".

[pmid14531806-7] ^ ^a ^b ^c ^d ^e ^f ^g ^h Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (November 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.

[pmid12471024-8] Gentzsch M, Cui L, Mengos A, Chang XB, Chen JH, Riordan JR (February 2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins". J. Biol. Chem. 278 (8): 6440–9. doi:10.1074/jbc.M211050200. PMID 12471024.

[pmid11051556-9] Wang S, Yue H, Derin RB, Guggino WB, Li M (September 2000). "Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity". Cell. 103 (1): 169–79. doi:10.1016/s0092-8674(00)00096-9. PMID 11051556. S2CID 16697781.

[pmid12837682-10] Pribanic S, Gisler SM, Bacic D, Madjdpour C, Hernando N, Sorribas V, Gantenbein A, Biber J, Murer H (October 2003). "Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells". Am. J. Physiol. Renal Physiol. 285 (4): F784-91. doi:10.1152/ajprenal.00109.2003. PMID 12837682. S2CID 25450845.

[pmid12754212-11] Silver DL, Wang N, Vogel S (August 2003). "Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels". J. Biol. Chem. 278 (31): 28528–32. doi:10.1074/jbc.M304109200. PMID 12754212.

[pmid17236129-12] Klopocki E, Schulze H, Strauss G, Ott CE, Hall J, Trotier F, Fleischhauer S, Greenhalgh L, Newbury-Ecob RA, Neumann LM, Habenicht R, König R, Seemanova E, Megarbane A, Ropers HH, Ullmann R, Horn D, Mundlos S (February 2007). "Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129.

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PDZK1

Interactions

Related gene problems

References

Further reading