PDLIM1

PDLIM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X62, 2PKT
Identifiers
Aliases	PDLIM1, CLIM1, CLP-36, CLP36, HEL-S-112, hCLIM1, PDZ and LIM domain 1
External IDs	OMIM: 605900; MGI: 1860611; HomoloGene: 9643; GeneCards: PDLIM1; OMA:PDLIM1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q23.33 Start 95,237,572 bp End 95,291,012 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 C3 Start 40,209,617 bp End 40,260,286 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung nasal epithelium mucosa of urinary bladder right lung pericardium gingival epithelium upper lobe of lung olfactory zone of nasal mucosa palpebral conjunctiva upper lobe of left lung Top expressed in ileum placenta jejunum duodenum esophagus colon uterus zygote lens genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity metal ion binding cadherin binding involved in cell-cell adhesion actin binding muscle alpha-actinin binding Cellular component cytoplasm cytoskeleton focal adhesion transcription regulator complex Z discdkac stress fiber filamentous actin Biological process response to hypoxia regulation of transcription, DNA-templated response to oxidative stress cell-cell adhesion positive regulation of nucleic acid-templated transcription heart development actin cytoskeleton organization muscle structure development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9124 54132 Ensembl ENSG00000107438 ENSMUSG00000055044 UniProt O00151 O70400 RefSeq (mRNA) NM_020992 NM_016861 RefSeq (protein) NP_066272 NP_058557 Location (UCSC) Chr 10: 95.24 – 95.29 Mb Chr 19: 40.21 – 40.26 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

PDZ and LIM domain protein 1 is a protein that in humans is encoded by the PDLIM1 gene.

Interactions

PDLIM1 has been shown to interact with:

• Actinin alpha 4,
• Actinin, alpha 1,
• Estrogen receptor alpha, and
• RNF12.

Further reading

• Wang H, Harrison-Shostak DC, Lemasters JJ, Herman B (1996). "Cloning of a rat cDNA encoding a novel LIM domain protein with high homology to rat RIL". Gene. 165 (2): 267–71. doi:10.1016/0378-1119(95)00542-E. PMID 8522188.
• Kotaka M, Ngai SM, Garcia-Barcelo M, Tsui SK, Fung KP, Lee CY, Waye MM (1999). "Characterization of the human 36-kDa carboxyl terminal LIM domain protein (hCLIM1)". J. Cell. Biochem. 72 (2): 279–85. doi:10.1002/(SICI)1097-4644(19990201)72:2<279::AID-JCB12>3.0.CO;2-7. PMID 10022510. S2CID 23811125.
• Vallenius T, Luukko K, Mäkelä TP (2000). "CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4". J. Biol. Chem. 275 (15): 11100–5. doi:10.1074/jbc.275.15.11100. PMID 10753915.
• Bauer K, Kratzer M, Otte M, de Quintana KL, Hagmann J, Arnold GJ, Eckerskorn C, Lottspeich F, Siess W (2001). "Human CLP36, a PDZ-domain and LIM-domain protein, binds to alpha-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells". Blood. 96 (13): 4236–45. doi:10.1182/blood.V96.13.4236. PMID 11110697.
• Ostendorff HP, Peirano RI, Peters MA, Schlüter A, Bossenz M, Scheffner M, Bach I (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors". Nature. 416 (6876): 99–103. Bibcode:2002Natur.416...99O. doi:10.1038/416099a. PMID 11882901. S2CID 4426785.
• Vallenius T, Mäkelä TP (2003). "Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein". J. Cell Sci. 115 (Pt 10): 2067–73. doi:10.1242/jcs.115.10.2067. PMID 11973348.
• Kioussi C, Briata P, Baek SH, Rose DW, Hamblet NS, Herman T, Ohgi KA, Lin C, Gleiberman A, Wang J, Brault V, Ruiz-Lozano P, Nguyen HD, Kemler R, Glass CK, Wynshaw-Boris A, Rosenfeld MG (2003). "Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development". Cell. 111 (5): 673–85. doi:10.1016/S0092-8674(02)01084-X. PMID 12464179. S2CID 16108479.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Miehe U, Kadyrov M, Neumaier-Wagner P, Bartz C, Rath W, Huppertz B (2007). "Expression of the actin stress fiber-associated protein CLP36 in the human placenta". Histochem. Cell Biol. 126 (4): 465–71. doi:10.1007/s00418-006-0182-5. PMID 16609848. S2CID 22394948.