PARP10

PARP10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DHX, 3HKV
Identifiers
Aliases	PARP10, ARTD10, poly(ADP-ribose) polymerase family member 10
External IDs	OMIM: 609564; MGI: 3712326; HomoloGene: 53133; GeneCards: PARP10; OMA:PARP10 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	144,012,772 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	76,127,641 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; pancreatic ductal cell; ; right uterine tube; ; spleen; ; appendix; ; lymph node; ; right testis; ; tendon of biceps brachii; ; left testis; ; right lobe of liver;
	Top expressed in
	granulocyte; ; thymus; ; right kidney; ; mesenteric lymph nodes; ; duodenum; ; lip; ; spleen; ; proximal tubule; ; left lobe of liver; ; submandibular gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; K63-linked polyubiquitin modification-dependent protein binding; protein binding; glycosyltransferase activity; NAD+ ADP-ribosyltransferase activity; protein ADP-ribosylase activity;
Cellular component	cytoplasm; nucleus; nucleolus; cytosol; intracellular membrane-bounded organelle;
Biological process	negative regulation of protein K63-linked ubiquitination; protein auto-ADP-ribosylation; negative regulation of NF-kappaB transcription factor activity; protein ADP-ribosylation; negative regulation of fibroblast proliferation; negative regulation of gene expression; NAD biosynthesis via nicotinamide riboside salvage pathway; protein poly-ADP-ribosylation; translesion synthesis; protein mono-ADP-ribosylation; DNA repair; cellular response to DNA damage stimulus;
	Sources:Amigo / QuickGO
Orthologs
	84875
	671535
	ENSG00000178685
	ENSMUSG00000063268
	Q53GL7
	Q8CIE4
	NM_032789; NM_001317895
	NM_001163575; NM_001163576
	NP_001304824; NP_116178
	NP_001157047; NP_001157048
	Wikidata
View/Edit Human	View/Edit Mouse

Poly [ADP-ribose] polymerase 10 is an enzyme that in humans is encoded by the PARP10 gene.^[5]^[6]

Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005).[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178685 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063268 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ame JC, Spenlehauer C, de Murcia G (Jul 2004). "The PARP superfamily". BioEssays. 26 (8): 882–93. doi:10.1002/bies.20085. PMID 15273990. S2CID 25024719.
^ ^a ^b "Entrez Gene: PARP10 poly (ADP-ribose) polymerase family, member 10".

Chou HY, Chou HT, Lee SC (2006). "CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10)". J. Biol. Chem. 281 (22): 15201–7. doi:10.1074/jbc.M506745200. PMID 16455663.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Yu M, Schreek S, Cerni C, et al. (2005). "PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation". Oncogene. 24 (12): 1982–93. doi:10.1038/sj.onc.1208410. PMID 15674325. S2CID 13330538.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178685 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000063268 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15273990-5] Ame JC, Spenlehauer C, de Murcia G (Jul 2004). "The PARP superfamily". BioEssays. 26 (8): 882–93. doi:10.1002/bies.20085. PMID 15273990. S2CID 25024719.

[entrez-6] "Entrez Gene: PARP10 poly (ADP-ribose) polymerase family, member 10".

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References

Further reading