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PAPSS1

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PAPSS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPAPSS1, ATPSK1, PAPSS, SK1, 3'-phosphoadenosine 5'-phosphosulfate synthase 1
External IDsOMIM: 603262; MGI: 1330587; HomoloGene: 81740; GeneCards: PAPSS1; OMA:PAPSS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005443

NM_001289477
NM_001289478
NM_001289479
NM_011863

RefSeq (protein)

NP_005434

NP_001276406
NP_001276407
NP_001276408
NP_035993

Location (UCSC)Chr 4: 107.59 – 107.72 MbChr 3: 131.27 – 131.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 is an enzyme that in humans is encoded by the PAPSS1 gene.[5][6][7]

Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM][7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138801Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028032Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Girard JP, Baekkevold ES, Amalric F (May 1998). "Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetase". FASEB J. 12 (7): 603–12. doi:10.1096/fasebj.12.7.603. PMID 9576487. S2CID 19530341.
  6. ^ ul Haque MF, King LM, Krakow D, Cantor RM, Rusiniak ME, Swank RT, Superti-Furga A, Haque S, Abbas H, Ahmad W, Ahmad M, Cohn DH (Oct 1998). "Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse". Nat Genet. 20 (2): 157–62. doi:10.1038/2458. PMID 9771708. S2CID 13108930.
  7. ^ a b "Entrez Gene: PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1".

Further reading

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