PACSIN1

PACSIN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3HAH, 3HAI, 3Q84, 3QNI
Identifiers
Aliases	PACSIN1, SDPI, protein kinase C and casein kinase substrate in neurons 1
External IDs	OMIM: 606512; MGI: 1345181; HomoloGene: 22674; GeneCards: PACSIN1; OMA:PACSIN1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	34,535,229 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	27,930,456 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; superior frontal gyrus; ; postcentral gyrus; ; entorhinal cortex; ; middle temporal gyrus; ; primary visual cortex; ; dorsolateral prefrontal cortex; ; anterior cingulate cortex; ; right hemisphere of cerebellum; ; prefrontal cortex;
	Top expressed in
	pontine nuclei; ; piriform cortex; ; superior frontal gyrus; ; primary visual cortex; ; subiculum; ; dorsal tegmental nucleus; ; cerebellar cortex; ; neural layer of retina; ; primary motor cortex; ; prefrontal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytoskeletal protein binding; protein binding; phospholipid binding; lipid binding; identical protein binding;
Cellular component	cytoplasm; axon terminus; cytosol; endosome; cell projection; membrane; myelin sheath; plasma membrane; synapse; ruffle membrane; cell junction; perinuclear region of cytoplasm; neuron projection; cytoplasmic vesicle membrane; cytoplasmic vesicle; COPI-coated vesicle; cytoskeleton; photoreceptor ribbon synapse; presynaptic endocytic zone;
Biological process	regulation of endocytosis; negative regulation of endocytosis; protein localization to membrane; neuron projection morphogenesis; endocytosis; actin filament organization; neuron development; positive regulation of dendrite development; plasma membrane tubulation; synaptic vesicle endocytosis; protein localization to plasma membrane; cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	29993
	23969
	ENSG00000124507
	ENSMUSG00000040276
	Q9BY11
	Q61644
	NM_001199583; NM_020804
	NM_001286743; NM_001286744; NM_011861; NM_178365
	NP_001186512; NP_065855
	NP_001273672; NP_001273673; NP_035991; NP_848142
	Wikidata
View/Edit Human	View/Edit Mouse

Protein kinase C and casein kinase substrate in neurons protein 1 also known as syndapin I^[5]^[6] is an enzyme that in humans is encoded by the PACSIN1 gene.^[7]

Interactions

PACSIN1 has been shown to interact with GTPases of the Dynamin family (Dynamin 1, 2 and 3). Based on this interaction, its localization and functional role the protein was named syndapin I (synaptic dynamin-associated protein I).

A variety of interactions have been published:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124507 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040276 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "PACSIN1 protein kinase C and casein kinase substrate in neurons 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-08-04.
^ "Pacsin1 protein kinase C and casein kinase substrate in neurons 1 [Mus musculus (house mouse)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-08-04.
^ Sumoy L, Pluvinet R, Andreu N, Estivill X, Escarceller M (Jan 2001). "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family". Gene. 262 (1–2): 199–205. doi:10.1016/S0378-1119(00)00531-X. PMID 11179684.
^ Qualmann B, Roos J, DiGregorio PJ, Kelly RB (February 1999). Pfeffer SR (ed.). "Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein". Molecular Biology of the Cell. 10 (2): 501–513. doi:10.1091/mbc.10.2.501. PMC 25183. PMID 9950691.
^ Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, et al. (Sep 2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis". The Journal of Biological Chemistry. 279 (38): 40091–9. doi:10.1074/jbc.M404899200. PMID 15252009.
^ ^a ^b ^c Modregger J, Ritter B, Witter B, Paulsson M, Plomann M (Dec 2000). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". Journal of Cell Science. 113 (24): 4511–21. doi:10.1242/jcs.113.24.4511. PMID 11082044.
^ Modregger J, DiProspero NA, Charles V, Tagle DA, Plomann M (Oct 2002). "PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains". Human Molecular Genetics. 11 (21): 2547–58. doi:10.1093/hmg/11.21.2547. PMID 12354780.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1)

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124507 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040276 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "PACSIN1 protein kinase C and casein kinase substrate in neurons 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-08-04.

[6] "Pacsin1 protein kinase C and casein kinase substrate in neurons 1 [Mus musculus (house mouse)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-08-04.

[pmid11179684-7] Sumoy L, Pluvinet R, Andreu N, Estivill X, Escarceller M (Jan 2001). "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family". Gene. 262 (1–2): 199–205. doi:10.1016/S0378-1119(00)00531-X. PMID 11179684.

[8] Qualmann B, Roos J, DiGregorio PJ, Kelly RB (February 1999). Pfeffer SR (ed.). "Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein". Molecular Biology of the Cell. 10 (2): 501–513. doi:10.1091/mbc.10.2.501. PMC 25183. PMID 9950691.

[pmid15252009-9] Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, et al. (Sep 2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis". The Journal of Biological Chemistry. 279 (38): 40091–9. doi:10.1074/jbc.M404899200. PMID 15252009.

[pmid11082044-10] Modregger J, Ritter B, Witter B, Paulsson M, Plomann M (Dec 2000). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". Journal of Cell Science. 113 (24): 4511–21. doi:10.1242/jcs.113.24.4511. PMID 11082044.

[pmid12354780-11] Modregger J, DiProspero NA, Charles V, Tagle DA, Plomann M (Oct 2002). "PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains". Human Molecular Genetics. 11 (21): 2547–58. doi:10.1093/hmg/11.21.2547. PMID 12354780.

[pmid16189514-12] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

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Interactions

References

Further reading

External links