Orotidine 5'-monophosphate
Appearance
(Redirected from Orotidine 5' -monophosphate)
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Names | |
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IUPAC name
2,6-Dioxo-3-(5-O-phosphono-β-D-ribofuranosyl)-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid
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Systematic IUPAC name
3-{(2R,3R,4S,5R)-3,4-Dihydroxy-6-[(phosphonooxy)methyl]oxolan-2-yl}-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid | |
Other names
Orotidylic acid,
OMP | |
Identifiers | |
3D model (JSmol)
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ChemSpider | |
MeSH | Orotidine+5'-monophosphate |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C10H13N2O11P | |
Molar mass | 368.191 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Orotidine 5'-monophosphate (OMP), also known as orotidylic acid, is a pyrimidine nucleotide[1] which is the last intermediate in the biosynthesis of uridine monophosphate.[2] OMP is formed from orotate and phosphoribosyl pyrophosphate by the enzyme orotate phosphoribosyltransferase.
In humans, the enzyme UMP synthase converts OMP into uridine 5'- monophosphate.[2] If UMP synthase is defective, orotic aciduria can result.[2]
References
[edit]- ^ PubChem. "Orotidine-5'-monophosphate". pubchem.ncbi.nlm.nih.gov. Retrieved 2023-01-26.
- ^ a b c "UMPS uridine monophosphate synthetase [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2023-01-26.