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ORC5

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(Redirected from ORC5 (gene))
ORC5
Identifiers
AliasesORC5, ORC5L, ORC5P, ORC5T, PPP1R117, origin recognition complex subunit 5
External IDsOMIM: 602331; MGI: 1347044; HomoloGene: 37636; GeneCards: ORC5; OMA:ORC5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001197292
NM_002553
NM_181747

NM_011959

RefSeq (protein)

NP_002544
NP_859531

NP_036089

Location (UCSC)Chr 7: 104.13 – 104.21 MbChr 5: 22.69 – 22.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Origin recognition complex subunit 5 is a protein that in humans is encoded by the ORC5 (ORC5L) gene.[5][6][7]

Function

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The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and 4L. Alternatively spliced transcript variants encoding distinct isoforms have been described.[7]

Interactions

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ORC5 has been shown to interact with:

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164815Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029012Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishiai M, Dean FB, Okumura K, Abe M, Moon KY, Amin AA, Kagotani K, Taguchi H, Murakami Y, Hanaoka F, O'Donnell M, Hurwitz J, Eki T (Dec 1997). "Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22". Genomics. 46 (2): 294–8. doi:10.1006/geno.1997.5003. PMID 9417919.
  6. ^ Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B (Dec 1998). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p". The Journal of Biological Chemistry. 273 (49): 32421–9. doi:10.1074/jbc.273.49.32421. PMID 9829972.
  7. ^ a b "Entrez Gene: ORC5L origin recognition complex, subunit 5-like (yeast)".
  8. ^ a b c d e f g h Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.
  9. ^ a b Quintana DG, Thome KC, Hou ZH, Ligon AH, Morton CC, Dutta A (Oct 1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". The Journal of Biological Chemistry. 273 (42): 27137–45. doi:10.1074/jbc.273.42.27137. PMID 9765232.
  10. ^ a b c Dhar SK, Delmolino L, Dutta A (Aug 2001). "Architecture of the human origin recognition complex". The Journal of Biological Chemistry. 276 (31): 29067–71. doi:10.1074/jbc.M103078200. PMID 11395502.
  11. ^ a b Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. doi:10.1074/jbc.M102493200. PMID 11323433.
  12. ^ Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron. 23 (1): 45–54. doi:10.1016/s0896-6273(00)80752-7. PMID 10402192. S2CID 781511.

Further reading

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