NETO1

NETO1
Identifiers
Aliases	NETO1, BCTL1, BTCL1, neuropilin and tolloid like 1
External IDs	OMIM: 607973; MGI: 2180216; HomoloGene: 16367; GeneCards: NETO1; OMA:NETO1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) Band 18q22.3 Start 72,742,314 bp End 72,868,146 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 E4 Start 86,394,952 bp End 86,506,718 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex Brodmann area 9 cingulate gyrus anterior cingulate cortex caudate nucleus putamen nucleus accumbens right frontal lobe testicle Amygdala Top expressed in dorsal striatum dentate gyrus of hippocampal formation granule cell nucleus accumbens subiculum olfactory tubercle hippocampus proper superior frontal gyrus Amygdala visual cortex primary visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function ionotropic glutamate receptor binding Cellular component integral component of membrane extracellular region cell junction postsynaptic membrane plasma membrane synapse excitatory synapse membrane postsynaptic density postsynaptic density membrane glutamatergic synapse integral component of postsynaptic density membrane Biological process visual learning regulation of neuronal synaptic plasticity receptor localization to synapse regulation of long-term neuronal synaptic plasticity memory positive regulation of excitatory postsynaptic potential regulation of kainate selective glutamate receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81832 246317 Ensembl ENSG00000166342 ENSMUSG00000050321 UniProt Q8TDF5 Q8R4I7 RefSeq (mRNA) NM_001201465 NM_138966 NM_138999 NM_153181 NM_001354017 NM_001354018 NM_001354020 NM_001354021 NM_001354022 NM_144946 NM_001360910 RefSeq (protein) NP_001188394 NP_620416 NP_620552 NP_001340946 NP_001340947 NP_001340949 NP_001340950 NP_001340951 NP_659195 NP_001347839 Location (UCSC) Chr 18: 72.74 – 72.87 Mb Chr 18: 86.39 – 86.51 Mb PubMed search
Wikidata
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Neuropilin (NRP) and tolloid (TLL)-like 1 is a protein that in humans is encoded by the NETO1 gene.

Function

This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].

Further reading

• Ng D, Pitcher GM, Szilard RK, Sertié A, Kanisek M, Clapcote SJ, Lipina T, Kalia LV, Joo D, McKerlie C, Cortez M, Roder JC, Salter MW, McInnes RR (February 2009). "Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning". PLOS Biology. 7 (2): e41. doi:10.1371/journal.pbio.1000041. PMC 2652390. PMID 19243221.
• Banno M, Koide T, Aleksic B, Yamada K, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Ikeda M, Inada T, Yoshikawa T, Iwata N, Ozaki N (2011). "A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population". PLOS ONE. 6 (12): e28929. Bibcode:2011PLoSO...628929B. doi:10.1371/journal.pone.0028929. PMC 3243668. PMID 22205981.
• Stöhr H, Berger C, Fröhlich S, Weber BH (March 2002). "A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain". Gene. 286 (2): 223–31. doi:10.1016/s0378-1119(02)00438-9. PMID 11943477.
• Benjamin DJ, Cesarini D, van der Loos MJ, Dawes CT, Koellinger PD, Magnusson PK, Chabris CF, Conley D, Laibson D, Johannesson M, Visscher PM (May 2012). "The genetic architecture of economic and political preferences" (PDF). Proceedings of the National Academy of Sciences of the United States of America. 109 (21): 8026–31. Bibcode:2012PNAS..109.8026B. doi:10.1073/pnas.1120666109. PMC 3361436. PMID 22566634.
• O'Donnell L, Soileau B, Heard P, Carter E, Sebold C, Gelfond J, Hale DE, Cody JD (August 2010). "Genetic determinants of autism in individuals with deletions of 18q". Human Genetics. 128 (2): 155–64. doi:10.1007/s00439-010-0839-y. PMID 20499253. S2CID 23659069.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.