Jump to content

NOL3

From Wikipedia, the free encyclopedia
(Redirected from NOL3 (gene))

NOL3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNOL3, ARC, FCM, MYP, NOP, NOP30, nucleolar protein 3, MYOCL1
External IDsOMIM: 605235; MGI: 1925938; HomoloGene: 31208; GeneCards: NOL3; OMA:NOL3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030152

RefSeq (protein)

NP_084428

Location (UCSC)Chr 16: 67.17 – 67.18 MbChr 8: 106 – 106.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleolar protein 3 is a protein that in humans is encoded by the NOL3 gene.[5][6]

Nol3 has been shown to be induced in multiple cancer types and acts as a repressor of apoptosis leading to resistance and proliferation.[7][8] Paradoxically, loss of Nol3 also leads to hematological disruption in mice resulting in a myeloproliferative neoplasm resembling primary myelofibrosis (PMF), and its deletion has also been detected in patient samples of PMF. [9]

Interactions

[edit]

NOL3 has been shown to interact with SFRS9[10] and Caspase 8.[5]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140939Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014776Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Koseki T, Inohara N, Chen S, Núñez G (Jun 1998). "ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5156–60. Bibcode:1998PNAS...95.5156K. doi:10.1073/pnas.95.9.5156. PMC 20230. PMID 9560245.
  6. ^ "Entrez Gene: NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)".
  7. ^ Wang M, Qanungo S, Crow MT, Watanabe M, Nieminen AL (2005). "Apoptosis repressor with caspase recruitment domain (ARC) is expressed in cancer cells and localizes to nuclei". FEBS Lett. 579 (11): 2411–5. Bibcode:2005FEBSL.579.2411W. doi:10.1016/j.febslet.2005.03.040. PMID 15848180. S2CID 28842286.
  8. ^ Mercier I, Vuolo M, Madan R, Xue X, Levalley AJ, Ashton AW, Jasmin JF, Czaja MT, Lin EY, Armstrong RC, Pollard JW, Kitsis RN (2005). "ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer and confers chemo- and radiation-resistance". Cell Death Differ. 12 (6): 682–6. doi:10.1038/sj.cdd.4401631. PMID 15861191.
  9. ^ Stanley RF, Piszczatowski RT, Bartholdy B, Mitchell K, McKimpson WM, Narayanagari S, Walter D, Todorova TI, Hirsch C, Makashima H, Will B, McMahon C, Gritsman K, Maciejewski JP, Kitsis RN, Steidl U (2017). "A myeloid tumor suppressor role for NOL3". J. Exp. Med. 214 (3): 753–771. doi:10.1084/jem.20162089. PMC 5339683. PMID 28232469.
  10. ^ Stoss O, Schwaiger FW, Cooper TA, Stamm S (Apr 1999). "Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c". J. Biol. Chem. 274 (16): 10951–62. doi:10.1074/jbc.274.16.10951. PMID 10196175.

Further reading

[edit]