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Meloxicam

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Meloxicam
Clinical data
Trade namesMobic, others
AHFS/Drugs.comMonograph
MedlinePlusa601242
License data
Pregnancy
category
Routes of
administration		By mouth, intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability89%[7]
Protein binding99.4%[7]
MetabolismLiver (CYP2C9 and 3A4-mediated)[7]
Elimination half-life20 hours[7]
ExcretionUrine and feces equally[7]
Identifiers
  • 4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard100.113.257 Edit this at Wikidata
Chemical and physical data
FormulaC14H13N3O4S2
Molar mass351.40 g·mol−1
3D model (JSmol)
  • Cc1cnc(s1)NC(=O)C\3=C(/O)c2ccccc2S(=O)(=O)N/3C
  • InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19) checkY
  • Key:ZRVUJXDFFKFLMG-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Meloxicam, sold under the brand name Mobic among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation in rheumatic diseases and osteoarthritis.[8][9] It is used by mouth or by injection into a vein.[9][10] It is recommended that it be used for as short a period as possible and at a low dose.[9]

Common side effects include abdominal pain, dizziness, swelling, headache, and a rash.[9] Serious side effects may include heart disease, stroke, kidney problems, and stomach ulcers.[9] Use is not recommended in the third trimester of pregnancy.[9] It blocks cyclooxygenase-2 (COX-2) more than it blocks cyclooxygenase-1 (COX-1).[9] It is in the oxicam family of chemicals and is closely related to piroxicam.[9]

Meloxicam was patented in 1977 and approved for medical use in the United States in 2000.[9][11] It was developed by Boehringer Ingelheim; however, it is also available as a generic medication.[9] In 2022, it was the 29th most commonly prescribed medication in the United States, with more than 18 million prescriptions.[12][13] An intravenous version of meloxicam (Anjeso) was approved for medical use in the United States in February 2020.[14][10]

Adverse effects

[edit]
See also: Nonsteroidal anti-inflammatory drug

Meloxicam use can result in gastrointestinal toxicity and bleeding, headaches, rash, and very dark or black stool (a sign of intestinal bleeding). It has fewer gastrointestinal side effects than diclofenac,[15] piroxicam,[16] naproxen,[17] and perhaps all other NSAIDs which are not COX-2 selective.[15]

In October 2020, the U.S. Food and Drug Administration (FDA) required the drug label to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid.[18][19] They recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy.[18][19]

Cardiovascular

[edit]

Like other NSAIDs, its use is associated with an increased risk of cardiovascular events such as heart attack and stroke.[20] Although meloxicam inhibits formation of thromboxane A, it does not appear to do so at levels that would interfere with platelet function.[21][22] A pooled analysis of randomized, controlled studies of meloxicam therapy of up to 60 days duration found that meloxicam was associated with a statistically significantly lower number of thromboembolic complications than the NSAID diclofenac (0.2% versus 0.8% respectively) but a similar incidence of thromboembolic events to naproxen and piroxicam.[23]

People with hypertension, high cholesterol, or diabetes are at risk for cardiovascular side effects. People with family history of heart disease, heart attack, or stroke should tell their treating physician as the potential for serious cardiovascular side effects is significant.[24][25]

Gastrointestinal

[edit]

NSAIDs cause an increase in the risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. Elderly patients are at greater risk for serious gastrointestinal events.[26]

Mouth

[edit]

It is recommended to withhold meloxicam use for at least four to six half-lives prior to surgical or dental procedures due to increased risk for taste perversion, ulcerative stomatitis and dry mouth.[medical citation needed]

Mechanism of action

[edit]
Main article: Non-steroidal anti-inflammatory drug

Meloxicam blocks cyclooxygenase (COX), the enzyme responsible for converting arachidonic acid into prostaglandin H2—the first step in the synthesis of prostaglandins, which are mediators of inflammation. Meloxicam has been shown, especially at low therapeutic doses, to selectively inhibit COX-2 over COX-1.[7]

Meloxicam concentrations in synovial fluid range from 40% to 50% of those in plasma. The free fraction in synovial fluid is 2.5 times higher than in plasma, due to the lower albumin content in synovial fluid as compared to plasma. The significance of this penetration is unknown,[26] but it may account for the fact that it performs exceptionally well in treatment of arthritis in animal models.[27]

Pharmacokinetics

[edit]

Absorption

[edit]

The bioavailability of meloxicam is decreased when administered orally compared to an equivalent IV bolus dose. Different oral formulations of meloxicam are not bioequivalent.[9] Use of oral meloxicam following a high-fat breakfast increases the mean peak drug levels by about 22%; however, the manufacturer does not make any specific meal recommendations. In addition, the use of antacids does not show pharmacokinetic interactions.[4] With chronic dosing, the time to maximum plasma concentration following oral administration is approximately 5–6 hours.[28]

Distribution

[edit]

The mean volume of distribution of meloxicam is approximately 10 L. It is highly protein-bound, mainly to albumin.[22][28]

Metabolism

[edit]

Meloxicam is extensively metabolized in the liver by the enzymes CYP2C9 and CYP3A4 (minor) into four inactive metabolites. Peroxidase activity is thought to be responsible for the other two remaining metabolites.[4][29]

Excretion

[edit]

Meloxicam is predominantly excreted in the form of metabolites and occurs to equal extents in the urine and feces.[4] Traces of unchanged parent drug are found in urine and feces.[4] The mean elimination half-life ranges from 15 to 20 hours.[4]

Specific populations

[edit]

Use of meloxicam is not recommended in people with peptic ulcer disease or increased gastrointestinal bleed risk, including those over 75 years of age or those taking medications associated with bleeding risk.[30]

Adverse events have been found to be dose-dependent and associated with length of treatment.[30][4]

Veterinary use

[edit]

Meloxicam is used in veterinary medicine mainly to treat dogs,[31][32] but also sees off-label use in other animals such as cattle and exotics.[33][34] In the European Union and other countries it is not considered off-label and can be used in cattle, pigs, horses, dogs, cats and guinea pigs.[35] It has also been investigated as an alternative to diclofenac by the Royal Society for the Protection of Birds (RSPB) to prevent deaths of vultures.[36]

Depending on the animal species, each country or union of countries applies different guidelines or legal frameworks for the use of the drug, as well as different recorded side effects. The most common side effects in dogs include gastrointestinal irritation (vomiting, diarrhea, and ulceration).[31] As far as the perioperative administration is concerned, in healthy dogs given meloxicam, no perioperative adverse effects on the cardiovascular system have been reported at recommended dosages.[37] Perioperative administration of meloxicam to cats did not affect postoperative respiratory rate nor heart rate.[38]

Use of meloxicam in cats

[edit]

The issue of using meloxicam in cats involves conflicting guidelines, differing legislation, and a narrow therapeutic safety margin that can easily turn the drug from cure to poison. More specifically:

US Policy vs EU Policy

[edit]

The American FDA (Food & Drug Administration) approves the use of meloxicam in cats only in injectable form and only as a one-time injection given before surgery.[39][40] It does not approve meloxicam oral suspension for cats and it does not approve meloxicam spray for cats because after reviewing numerous reports of meloxicam side effects in cats, it has identified many cases of acute renal failure and death and has added the following boxed warning to the products' label: "Repeated use of meloxicam in cats has been associated with acute renal failure and death. Do not administer additional injectable or oral meloxicam to cats. See Contraindications, Warnings, and Precautions for detailed information."[41]

In contrast, in the European Union and other continents or countries, the use of the drug in cats is allowed with no such warning.[42][43] The product instruction leaflet for meloxicam for cats in the form of oral suspension 0.5 mg/ml states that: "Typical adverse reactions of NSAIDs such as loss of appetite, vomiting, diarrhoea, faecal occult blood, apathy and renal failure have occasionally been reported. These side effects are in most cases transient and disappear following termination of the treatment but in very rare cases may be serious or fatal."[44]

Apart from the obvious difference in policy on this specific issue, there is also a huge disparity in the findings between the US and the EU. Specifically, as repeated above, in the US, numerous reports of side effects are observed, with many cases of acute renal failure and death among them, while in the EU, side effects have occasionally been reported, are usually transient, and death occurs only in very rare cases. To further illustrate the gap with numbers, using the typical convention for adverse reactions, 'very common' is defined as more than 1 in 10 treated animals, while 'very rare' is defined as less than 1 in 10,000 treated animals.

Finally, the above data demonstrate that the death of a large number of cats in an extensive region, such as the United States, is not sufficient to bring about a global policy change. On the contrary, each country or group of countries waits for its own fatalities before taking similar actions.

Contradictory Product Instructions Across Countries

[edit]

Some meloxicam products for cats that are available and sold include: Loxicom, Metacam, Meloxidyl, Melosus, Meloxoral. On the official website of at least two of these products, it is observed that by changing the country selection, the usage instructions are also modified, adapting to the respective national policies. Specifically:

Meloxidyl® for cats by Ceva Animal Health Ltd is a product specifically designed for cats, that is available on the market both in injectable form and in the form of oral suspension.[45] However, the main page of the official website of the same meloxicam product, written with a .com extension, includes the FDA warning message in a black box and additionally states at the bottom: "Important Safety Information: DO NOT USE [...] ORAL SUSPENSION IN CATS. Acute renal failure and death have been associated with the use of meloxicam in cats."[46]

The same applies to the website for the Metacam product by Boehringer-Ingelheim. In the American version of the website, when navigating to the specific product METACAM® (meloxicam oral suspension) under the 'animal products' category,[47] a new page opens,[48] where at the bottom, an unmovable dark box reads: "IMPORTANT SAFETY INFORMATION, METACAM® (meloxicam oral suspension) is for use in dogs only. METACAM (meloxicam) Solution for Injection is approved for use in dogs or cats (not indicated for osteoarthritis in cats). Repeated use of meloxicam in cats has been associated with acute renal failure and death. Do not administer additional injectable or oral meloxicam to cats." Οn the same website, but with a European Union country selected,[49] the product Metacam 0.5mg/ml for cats appears. Clicking on the link opens a new page[50] where it is mentioned that the product is used for both cats and dogs.

According to the above, it is observed that the exact same product, when used for the same species (cats), exhibits stark differences worldwide: in some places, it warns of frequent incidents of death, while in others, it is available on the market and used even for simple cases of joint pain relief.

Dosage and Safety Margin

[edit]

The data sheets for meloxicam products for cats also state that: "Meloxicam has a narrow therapeutic safety margin in cats and clinical signs of overdose may be seen at relatively small overdose levels."[44] The dosage policy for meloxicam oral suspension products for cats as described in the data sheets defines the amount administered as proportional to body weight. There is no separate dosage guideline for overweight or obese cats. Similarly, there is no separate dosage instruction for elderly cats.

This information is important because, shifting attention briefly to the human medical field, where more studies have been conducted, there are medical opinions suggesting that the typical dosage of certain medications can lead to toxicity if factors such as obesity[51] or the patient’s age[52] are not taken into account. Considering the above and returning to the world of cats, given that the therapeutic safety margin is considered to be narrow, it is worth questioning whether the relatively small overdose levels refer exclusively to the use of a slightly higher dose than the typical dosage, or whether factors such as obesity and/or age could turn even the typical dosage into an overdose. However, the instruction leaflet[44] does not recommend adjusting the dosage in such cases, and it appears no relevant research has been conducted.

Additional Studies

[edit]

Some additional information about giving meloxicam to cats from researchers is as follows: A peer-reviewed journal article cites NSAIDs, including meloxicam, as causing gastrointestinal upset and, at high doses, acute kidney injury and CNS signs such as seizures and comas in cats. It adds that cats have a low tolerance for NSAIDs.[53][54] Also, in another scientific journal there is talk of research according to which cats that received meloxicam had greater proteinuria at 6 months than cats that received placebo. It was concluded that meloxicam should be used with caution in cats with chronic kidney disease.[55]

Pharmacokinetics

[edit]

In dogs, the absorption of meloxicam from the stomach is not affected by the presence of food,[56] with the peak concentration (Cmax) of meloxicam occurring in the blood 7–8 hours after administration.[56] The half-life of meloxicam is approximately 24 hours in dogs.[56] In the koala (Phascolarctos cinereus), very little meloxicam is absorbed into the blood after oral administration (that is, it has poor bioavailability).[57]

[edit]

United States

[edit]

2003: Meloxicam was approved in the U.S. for use in dogs for the management of pain and inflammation associated with osteoarthritis, as an oral (liquid) formulation of meloxicam.[58]

2003 (November): An injectable formulation for use in dogs was approved by the U.S. Food and Drug Administration (FDA).[59]

2004 (October): A formulation for use in cats was approved for use prior to surgery only.[60] This is an injectable meloxicam, indicated for as a single, one-time dose only, with specific and repeated warnings not to administer a second dose.[61]

2005 (January): The product insert added a warning in bold-face type: "Do not use in cats."[62]

2005: The FDA sent a Notice of Violation to the manufacturer for its promotional materials which included promotion of the drug for off-label use.[63]

2020 (February): A meloxicam injection was approved for use in the United States. Specifically, the FDA granted the approval of Anjeso to Baudax Bio.[10][64]

European Union

[edit]

In Europe the product is licensed for other anti-inflammatory benefits including relief from both acute and chronic pain in dogs. Meloxicam is also licensed for use in horses, to relieve the pain associated with musculoskeletal disorders.[65]

1998 (January): Meloxicam was authorised for use in cattle throughout the European Union, via a centralised marketing authorisation.[66]

2006: The first generic meloxicam product was approved.[66]

2024 (January): EMA issued an 'Opinion'[67] on a change to this medicine's authorisation with regard to the follow-up oral treatment after initial injectable administration in cats. This change remains as an 'Opinion', while the medication continues to be approved as usual.[68]

Other countries

[edit]

As of June 2008, meloxicam is registered for long-term use in cats in Australia, New Zealand, and Canada.[69]

In the United Kingdom, meloxicam is licensed for use in cats, guinea pigs, horses, and livestock including pigs and cattle. [70]

See also

[edit]

References

[edit]
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    "None of the meloxicam treatment groups demonstrated inhibition of platelet aggregation to either arachidonic acid (AC) or adenosine diphosphate (ADP). However, there were no significant changes in the platelet count, prothrombin and activated partial thromboplastin time in any of the meloxicam and indomethacin groups. Other crossover studies also confirmed that meloxicam 15 mg/day caused a major reduction of maximum thromboxane production, but no reduction in collagen- or AC-induced platelet aggregation.
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  49. ^ www.boehringer-ingelheim.com https://www.boehringer-ingelheim.com/animal-health/products. Retrieved 16 November 2024. {{cite web}}: Missing or empty |title= (help)
  50. ^ www.boehringer-ingelheim.com https://www.boehringer-ingelheim.com/animal-health/products/metacam-pets. Retrieved 16 November 2024. {{cite web}}: Missing or empty |title= (help)
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  59. ^ "NADA 141-219: Metacam (meloxicam) 5 mg/mL Solution for Injection" (PDF). U.S. Food and Drug Administration (FDA). 12 November 2003. Archived from the original (PDF) on 15 November 2017. Retrieved 8 August 2019.
  60. ^ "Metacam 5 mg/mL Solution for Injection, Supplemental Approval" (PDF). U.S. Food and Drug Administration (FDA). 28 October 2004. Archived from the original (PDF) on 15 November 2017. Retrieved 8 August 2019.
  61. ^ See the manufacturer's FAQ Archived 2 July 2011 at the Wayback Machine on its website, and its clinical dosing instructions for cats. Archived 6 September 2008 at the Wayback Machine
  62. ^ "Client Information Sheet For Metacam (meloxicam) 1.5 mg/mL Oral Suspension" (PDF). Food and Drug Administration (FDA). January 2005. Archived from the original (PDF) on 15 November 2017. Metacam is a prescription non-steroidal anti-inflammatory drug (NSAID) that is used to control pain and inflammation (soreness) due to osteoarthritis in dogs. Osteoarthritis (OA) is a painful condition caused by "wear and tear" of cartilage and other parts of the joints that may result in the following changes or signs in your dog: Limping or lameness, decreased activity or exercise (reluctance to stand, climb stairs, jump or run, or difficulty in performing these activities), stiffness or decreased movement of joints. Metacam is given to dogs by mouth. Do not use Metacam Oral Suspension in cats. Acute kidney injury and death have been associated with the use of meloxicam in cats.
  63. ^ "Notice of Violation" (PDF). U.S. Food and Drug Administration (FDA). 19 April 2005. Archived from the original (PDF) on 13 January 2017. Retrieved 8 August 2019.
  64. ^ "Anjeso (meloxicam) injection, for intravenous use" (PDF). U.S. Food and Drug Administration (FDA). February 2020. Archived (PDF) from the original on 22 February 2020. Retrieved 21 February 2020.
  65. ^ Maddison JE, Page SW, Church D, eds. (2008). "Meloxicam". Small animal clinical pharmacology (2nd ed.). Edinburgh: Saunders/Elsevier. pp. 301–302. ISBN 9780702028588.
  66. ^ a b Wright E (March 2007). "Generic and biosimilar medicinal products in the European Union" (PDF). Chemistry Today. 25 (2): 4–6. Archived (PDF) from the original on 28 January 2020. Retrieved 28 January 2020.
  67. ^ "Metacam - opinion on variation to marketing authorisation | European Medicines Agency (EMA)". www.ema.europa.eu. 19 January 2024. Retrieved 16 November 2024.
  68. ^ "Metacam | European Medicines Agency (EMA)". www.ema.europa.eu. 31 July 2006. Retrieved 16 November 2024.
  69. ^ Gaschen FP, Schaer M, eds. (2016). "Recent NSAID developments". Clinical medicine of the dog and cat (3rd ed.). CRC Press. ISBN 9781482226065. Archived from the original on 1 September 2020. Retrieved 28 January 2020.
  70. ^ "Product Information Database". Veterinary Medicines Directorate. DEFRA. Retrieved 29 March 2023.
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