Methylprednisolone: Difference between revisions
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Methylprednisolone has some serious side effects if taken long-term, including weight gain, [[glaucoma]], [[osteoporosis]] and [[psychosis]], especially when used at high dosage. The most serious side effect occurs after the adrenal glands cease natural production of [[cortisol]], which methylprednisolone will replace. Abrupt cessation of the drug after this occurs can result in a condition known as [[Addison's disease#Addisonian crisis|Addisonian crisis]], which can be fatal. To prevent this, the drug is usually prescribed with a tapering dosage, including a pre-dosed "dose pack" detailing a specific number of pills to take at designated times over a several-day period. Pharmacists sometimes advise that this drug can cause sleeplessness and "down" moods. |
Methylprednisolone has some serious side effects if taken long-term, including weight gain, [[glaucoma]], [[osteoporosis]] and [[psychosis]], especially when used at high dosage. The most serious side effect occurs after the adrenal glands cease natural production of [[cortisol]], which methylprednisolone will replace. Abrupt cessation of the drug after this occurs can result in a condition known as [[Addison's disease#Addisonian crisis|Addisonian crisis]], which can be fatal. To prevent this, the drug is usually prescribed with a tapering dosage, including a pre-dosed "dose pack" detailing a specific number of pills to take at designated times over a several-day period. Pharmacists sometimes advise that this drug can cause sleeplessness and "down" moods. |
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All in all, this is a great drug! :) |
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==Additional images== |
==Additional images== |
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Revision as of 16:39, 5 December 2011
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| Clinical data | |
|---|---|
| Trade names | Medrol, Meprolone |
| Other names | (6α, 11β)-11,17,21-trihydroxy-6-methyl-pregna-1,4-diene-3,20-dione |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682795 |
| License data | |
| Pregnancy category |
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| Routes of administration | IV, IM, IV Infusion, Oral, Rectal, Topical |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Protein binding | 78% |
| Metabolism | liver primarily, kidney, tissues; CYP450: 3A4 substrate |
| Elimination half-life | urine; Half-life: 18-26h (biological) |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.001.343 |
| Chemical and physical data | |
| Formula | C22H30O5 |
| Molar mass | 374.471 g/mol g·mol−1 |
| 3D model (JSmol) | |
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Methylprednisolone is a synthetic glucocorticoid or corticosteroid drug. It is marketed in the USA and Canada under the brand names Medrol and Solu-Medrol.[1] It is also available as a generic drug.
It is a variant of prednisolone, methylated at carbon 6 of the B ring.
Uses
Like most adrenocortical steroids, methylprednisolone is typically used for its anti-inflammatory effects. However, glucocorticoids have a wide range of effects, including changes to metabolism and immune responses. The list of medical conditions for which methylprednisolone is prescribed is rather long, and is similar to other corticosteroids such as prednisolone. Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases. It is used both in the treatment of acute periods and long-term management of autoimmune diseases, most notably Systemic lupus erythematosus. Also for use as a treatment for Multiple Sclerosis.
Methylprednisolone is also prescribed for nonpenetrating spinal cord injuries. It has been shown that a dose of 30 mg/kg IV followed by IV drip at 5.4 mg/kg/hr for 23 hours improves sensory and motor recovery if given within eight hours of the injury.[citation needed]
Methylprednisolone can be injected into the spinal cord by pain management specialists for the treatment of chronic pain caused by injuries or osteoarthritis.
It is also used for vestibular neuritis.[2]
Side effects
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Methylprednisolone has some serious side effects if taken long-term, including weight gain, glaucoma, osteoporosis and psychosis, especially when used at high dosage. The most serious side effect occurs after the adrenal glands cease natural production of cortisol, which methylprednisolone will replace. Abrupt cessation of the drug after this occurs can result in a condition known as Addisonian crisis, which can be fatal. To prevent this, the drug is usually prescribed with a tapering dosage, including a pre-dosed "dose pack" detailing a specific number of pills to take at designated times over a several-day period. Pharmacists sometimes advise that this drug can cause sleeplessness and "down" moods. All in all, this is a great drug! :)
Additional images
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4mg Methylprednisolone tablets by Sandoz
See also
- Guanacastepene A - also composed as C22H30O5
References
- ^ Methylprednisolone - Compound Summary PubChem
- ^ Strupp M, Zingler VC, Arbusow V, Niklas D, Maag KP, Dieterich M, Bense S, Theil D, Jahn K, Brandt T (2004). "Methylprednisolone, valacyclovir, or the combination for vestibular neuritis" (PDF). N. Engl. J. Med. 351 (4): 354–61. doi:10.1056/NEJMoa033280. PMID 15269315.
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