MT1E

MT1E
Identifiers
Aliases	MT1E, MT1, MTD, MT-1E, MT-IE, metallothionein 1E
External IDs	OMIM: 156351; HomoloGene: 138433; GeneCards: MT1E; OMA:MT1E - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	56,627,112 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; mucosa of ileum; ; external globus pallidus; ; pericardium; ; right lobe of liver; ; synovial joint; ; internal globus pallidus; ; kidney tubule; ; left uterine tube; ; pars reticulata;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; metal ion binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; nucleus;
Biological process	negative regulation of growth; cellular response to cadmium ion; cellular response to zinc ion; cellular zinc ion homeostasis; detoxification of copper ion; cellular response to copper ion;
	Sources:Amigo / QuickGO
Orthologs
	4493
	n/a
	ENSG00000169715
	n/a
	P04732
	n/a
	NM_175617; NM_001363555
	n/a
	NP_783316; NP_001350484
	n/a
	Wikidata
View/Edit Human

Metallothionein-1E is a protein that in humans is encoded by the MT1E gene.^[3]^[4]^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169715 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome 16". Proc Natl Acad Sci U S A. 81 (17): 5494–8. Bibcode:1984PNAS...81.5494K. doi:10.1073/pnas.81.17.5494. PMC 391732. PMID 6089206.
^ Schmidt CJ, Jubier MF, Hamer DH (Jul 1985). "Structure and expression of two human metallothionein-I isoform genes and a related pseudogene". J Biol Chem. 260 (12): 7731–7. doi:10.1016/S0021-9258(17)39668-0. PMID 2581970.
^ "Entrez Gene: MT1E metallothionein 1E".

West AK, Stallings R, Hildebrand CE, et al. (1991). "Human metallothionein genes: structure of the functional locus at 16q13". Genomics. 8 (3): 513–8. doi:10.1016/0888-7543(90)90038-V. PMID 2286373.
Le Beau MM, Diaz MO, Karin M, Rowley JD (1985). "Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia". Nature. 313 (6004): 709–11. Bibcode:1985Natur.313..709L. doi:10.1038/313709a0. PMID 3856101. S2CID 4321473.
Carter AD, Felber BK, Walling MJ, et al. (1985). "Duplicated heavy metal control sequences of the mouse metallothionein-I gene". Proc. Natl. Acad. Sci. U.S.A. 81 (23): 7392–6. doi:10.1073/pnas.81.23.7392. PMC 392152. PMID 6095291.
Kondo Y, Kuo SM, Lazo JS (1994). "Interleukin-1 beta-mediated metallothionein induction and cytoprotection against cadmium and cis-diamminedichloroplatinum". J. Pharmacol. Exp. Ther. 270 (3): 1313–8. PMID 7932184.
Pauwels M, van Weyenbergh J, Soumillion A, et al. (1994). "Induction by zinc of specific metallothionein isoforms in human monocytes". Eur. J. Biochem. 220 (1): 105–10. doi:10.1111/j.1432-1033.1994.tb18603.x. PMID 8119276.
Vandeghinste N, Proost P, De Ley M (2000). "Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes". Cell. Mol. Biol. (Noisy-le-grand). 46 (2): 419–33. PMID 10774930.
Nguyen A, Jing Z, Mahoney PS, et al. (2000). "In vivo gene expression profile analysis of metallothionein in renal cell carcinoma". Cancer Lett. 160 (2): 133–40. doi:10.1016/S0304-3835(00)00534-6. PMID 11053642.
Oppermann B, Zhang W, Magabo K, Kantorow M (2001). "Identification and spatial analysis of metallothioneins expressed by the adult human lens". Invest. Ophthalmol. Vis. Sci. 42 (1): 188–93. PMC 2957813. PMID 11133866.
Garrett SH, Belcastro M, Sens MA, et al. (2001). "Acute exposure to arsenite induces metallothionein isoform-specific gene expression in human proximal tubule cells". J. Toxicol. Environ. Health A. 64 (4): 343–55. Bibcode:2001JTEHA..64..343G. doi:10.1080/152873901316981321. PMID 11693492. S2CID 43143430.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
Hawse JR, Cumming JR, Oppermann B, et al. (2003). "Activation of metallothioneins and alpha-crystallin/sHSPs in human lens epithelial cells by specific metals and the metal content of aging clear human lenses". Invest. Ophthalmol. Vis. Sci. 44 (2): 672–9. doi:10.1167/iovs.02-0018. PMC 2825746. PMID 12556398.
Sens D, Rossi M, Park S, et al. (2003). "Metallothionein isoform 1 and 2 gene expression in a human urothelial cell line (UROtsa) exposed to CdCl2 and NaAsO2". J. Toxicol. Environ. Health A. 66 (21): 2031–46. Bibcode:2003JTEHA..66.2031S. doi:10.1080/713853980. PMID 14555400.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Sun NN, Fastje CD, Wong SS, et al. (2005). "Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line". Toxicology and Industrial Health. 19 (7–10): 157–63. doi:10.1191/0748233703th185oa. PMID 15747776. S2CID 14394243.
Lederer CW, Torrisi A, Pantelidou M, et al. (2007). "Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis". BMC Genomics. 8: 26. doi:10.1186/1471-2164-8-26. PMC 1796866. PMID 17244347.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169715 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6089206-3] Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome 16". Proc Natl Acad Sci U S A. 81 (17): 5494–8. Bibcode:1984PNAS...81.5494K. doi:10.1073/pnas.81.17.5494. PMC 391732. PMID 6089206.

[pmid2581970-4] Schmidt CJ, Jubier MF, Hamer DH (Jul 1985). "Structure and expression of two human metallothionein-I isoform genes and a related pseudogene". J Biol Chem. 260 (12): 7731–7. doi:10.1016/S0021-9258(17)39668-0. PMID 2581970.

[entrez-5] "Entrez Gene: MT1E metallothionein 1E".

[1]

[2]

[3]

[4]

[5]

References

Further reading