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SEPX1

From Wikipedia, the free encyclopedia
(Redirected from MSRB1)
MSRB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMSRB1, SELR, SELX, SEPX1, SepR, HSPC270, methionine sulfoxide reductase B1, SELENOX, SELENOR
External IDsOMIM: 606216; MGI: 1351642; HomoloGene: 8455; GeneCards: MSRB1; OMA:MSRB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016332
NM_001382264
NM_001382265

NM_013759
NM_001346668

RefSeq (protein)

NP_057416
NP_001369193
NP_001369194

NP_001333597
NP_038787

Location (UCSC)Chr 16: 1.94 – 1.94 MbChr 17: 24.96 – 24.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Methionine-R-sulfoxide reductase B1 is an enzyme that in humans is encoded by the SEPX1 gene.[5][6]

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase B (MsrB) family, and it is expressed in a variety of adult and fetal tissues.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198736Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000075705Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lescure A, Gautheret D, Carbon P, Krol A (Feb 2000). "Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif". J Biol Chem. 274 (53): 38147–54. doi:10.1074/jbc.274.53.38147. PMID 10608886.
  6. ^ a b "Entrez Gene: SEPX1 selenoprotein X, 1".

Further reading

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