Mitochondrial ribosomal protein L30

MRPL30
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL30, L28MT, L30MT, MRP-L28, MRP-L30, MRPL28, MRPL28M, RPML28, mitochondrial ribosomal protein L30
External IDs	OMIM: 611838; MGI: 1333820; HomoloGene: 32675; GeneCards: MRPL30; OMA:MRPL30 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q11.2 Start 99,181,152 bp End 99,199,561 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 B Start 37,929,558 bp End 37,937,616 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle myocardium of left ventricle pancreatic ductal cell mucosa of ileum deltoid muscle cardiac muscle tissue of right atrium vastus lateralis muscle gingival epithelium biceps brachii Achilles tendon Top expressed in digastric muscle intercostal muscle sternocleidomastoid muscle brown adipose tissue medial ganglionic eminence triceps brachii muscle temporal muscle genital tubercle right ventricle tail of embryo More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome Cellular component mitochondrial inner membrane ribosome large ribosomal subunit mitochondrial large ribosomal subunit mitochondrion Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51263 107734 Ensembl ENSG00000185414 ENSMUSG00000026087 UniProt Q8TCC3 Q9D7N6 RefSeq (mRNA) NM_016503 NM_145212 NM_145213 NM_027098 NM_001356482 RefSeq (protein) NP_660213 NP_081374 NP_001343411 Location (UCSC) Chr 2: 99.18 – 99.2 Mb Chr 1: 37.93 – 37.94 Mb PubMed search
Wikidata
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39S ribosomal protein L30, mitochondrial is a protein that in humans is encoded by the MRPL30 gene.

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified at least two transcript variants encoding the same protein. Pseudogenes corresponding to this gene are found on chromosomes 6p and 12p.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Goldschmidt-Reisin S, Kitakawa M, Herfurth E, Wittmann-Liebold B, Grohmann L, Graack HR (December 1998). "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences". The Journal of Biological Chemistry. 273 (52): 34828–36. doi:10.1074/jbc.273.52.34828. PMID 9857009.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (September 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Zhang Z, Gerstein M (May 2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.

External links

• Overview of all the structural information available in the PDB for UniProt: Q8TCC3 (Human 39S ribosomal protein L30, mitochondrial (MRPL30)) at the PDBe-KB.