2-Hydroxy-3-morpholinopropanesulfonic acid

MOPSO
Names
	Preferred IUPAC name 2-Hydroxy-3-(morpholin-4-yl)propane-1-sulfonic acid
	Other names MOPSO, 3-morpholino-2-hydroxypropanesulfonic acid, 3-morpholino-2HOPSA
Identifiers
CAS Number	68399-77-9;
3D model (JSmol)	Interactive image;
ECHA InfoCard	100.063.607
EC Number	269-989-6;
PubChem CID	109333;
UNII	6XB7PS9THL ;
CompTox Dashboard (EPA)	DTXSID40887352 ;
	InChI InChI=1S/C7H15NO5S/c9-7(6-14(10,11)12)5-8-1-3-13-4-2-8/h7,9H,1-6H2,(H,10,11,12) Key: NUFBIAUZAMHTSP-UHFFFAOYSA-N;
	SMILES C1COCCN1CC(CS(=O)(=O)O)O;
Properties
Chemical formula	C7H15NO5S
Molar mass	225.259 g/mol
Appearance	White crystalline powder
Melting point	270–290 °C (518–554 °F; 543–563 K)
Acidity (pKa)	6.9
Hazards
	Occupational safety and health (OHS/OSH):
Main hazards	Irritant
	GHS labelling:
Signal word	Warning
Hazard statements	H315, H319, H335
Precautionary statements	P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
Flash point	Non-flammable
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

MOPSO is a zwitterionic organic chemical buffering agent; one of Good's buffers. MOPSO and MOPS (3-morpholinopropanesulfonic acid) are chemically similar, differing only in the presence of a hydroxyl group on the C-2 of the propane moiety. It has a useful pH range of 6.5-7.9 in the physiological range, making it useful for cell culture work. It has a pKa of 6.9 with ΔpKa/°C of -0.015 and a solubility in water at 0°C of 0.75 M.

MOPSO has been used as a buffer component for:^[4]

Copper analysis via:
- Flow injection micellar technique of the catalytic reaction of 3-methyl-2-benzothiazolinone hydrazone and N-ethyl-N-(2-hydroxy-3-sulfopropyl)-3,5-dimethoxyaniline
- Electrospray ionization quadrupole time-of-flight mass spectroscopy to measure MOPSO-copper chelated complexes
Discontinuous gel electrophoresis on rehydratable polyacrylamide gels
Buffered charcoal yeast extract agar
Fixing cells in urine in a buffered alcohol
Testing crude oil bioremediation products in marine environments

References

^ "Compound Summary for CID 109333". PubChem. 2005-03-27.
^ "MOPSO". Sigma-Aldrich.
^ "Biological Buffers". Sigma-Aldrich.
^ "MOPSO sodium salt" (PDF). Sigma-Aldrich.

[1] "Compound Summary for CID 109333". PubChem. 2005-03-27.

[2] "MOPSO". Sigma-Aldrich.

[3] "Biological Buffers". Sigma-Aldrich.

[4] "MOPSO sodium salt" (PDF). Sigma-Aldrich.

[1]

[2]

[3]

[4]

See also

References