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Protein-coding gene in the species Homo sapiens
MKL/megakaryoblastic leukemia 1 (also termed MRTFA/myocardin related transcription factor A) is a protein that in humans is encoded by the MKL1 gene .[ 5] [ 6] [ 7] [ 8]
The protein encoded by this gene is regulated by the actin cytoskeleton and is shuttled between the cytoplasm and the nucleus as a result of actin dynamics.[ 9] serum response factor ,[ 10] MKL2 and myocardin , with which it shares five key conserved structural domains.[ 11]
Clinical significance [ edit ] This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia .[ 8] [ 12]
Evalarted MKL1 expression is observed in breast cancer and can predict chemosensitivity and patient survival. MKL1 may be a promising biomarker of clinical value for breast cancer.[ 13]
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