Jump to content

Lutetium(III) chloride

From Wikipedia, the free encyclopedia
(Redirected from Lutetium chloride)
Lutetium(III) chloride
Names
IUPAC name
Lutetium(III) chloride
Other names
Lutetium chloride, lutetium trichloride
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.030.205 Edit this at Wikidata
EC Number
  • 233-240-1
RTECS number
  • OK8400000
UNII
  • InChI=1S/3ClH.Lu/h3*1H;/q;;;+3/p-3 checkY
    Key: AEDROEGYZIARPU-UHFFFAOYSA-K checkY
  • InChI=1S/3ClH.Lu/h3*1H;/q;;;+3/p-3
    Key: AEDROEGYZIARPU-DFZHHIFOAO
  • Key: AEDROEGYZIARPU-UHFFFAOYSA-K
  • Cl[Lu](Cl)Cl
Properties
LuCl3
Molar mass 281.325 g/mol
Appearance colorless or white monoclinic crystals
Density 3.98 g/cm3
Melting point 925 °C (1,697 °F; 1,198 K)[3]
Boiling point sublimes above 750°C[1]
soluble[2]
Structure
Monoclinic, mS16
C2/m, No. 12
Pharmacology
License data
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Irritant
GHS labelling:[4][5]
GHS07: Exclamation mark
Warning
H315, H319, H335
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g. chloroformFlammability 0: Will not burn. E.g. waterInstability 1: Normally stable, but can become unstable at elevated temperatures and pressures. E.g. calciumSpecial hazards (white): no code
2
0
1
Related compounds
Other anions
 Lutetium(III) oxide
Other cations
 Ytterbium(III) chloride
Scandium(III) chloride
Yttrium(III) chloride
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Lutetium(III) chloride or lutetium trichloride is the chemical compound composed of lutetium and chlorine with the formula LuCl3. It forms hygroscopic white monoclinic crystals[3] and also a hygroscopic hexahydrate LuCl3·6H2O.[6] Anhydrous lutetium(III) chloride has the YCl3 (AlCl3) layer structure with octahedral lutetium ions.[7]

Lutetium-177, a radioisotope that can be derived from lutetium(III) chloride, is used in targeted cancer therapies.[8] When lutetium-177 is attached to molecules that specifically target cancer cells, it can deliver localized radiation to destroy those cells while sparing surrounding healthy tissue.[9] This makes lutetium-177-based treatments especially valuable for cancers that are difficult to treat with traditional methods, such as neuroendocrine tumors and prostate cancer.[10] Additionally, lutetium(III) chloride is used in scintillators, materials that emit light when exposed to radiation.[11] These scintillators are crucial in detectors for gamma rays and other high-energy particles, used in both medical diagnostics and in scientific research.[12]

Reactions

[edit]

Pure lutetium metal can be produced from lutetium(III) chloride by heating it together with elemental calcium:[13]

2 LuCl3 + 3 Ca → 2 Lu + 3 CaCl2

See also

[edit]

References

[edit]
  1. ^ "Chemistry: Periodic Table: Lutetium: compound data (lutetium (III) chloride)". WebElements. Retrieved 2024-09-06.
  2. ^ Perry, Dale L.; Phillips, Sidney L. (1995), Handbook of Inorganic Compounds, CRC Press, p. 232, ISBN 0-8493-8671-3, retrieved 2008-06-27
  3. ^ a b Lide, David R. (1998), Handbook of Chemistry and Physics (87 ed.), Boca Raton, Florida: CRC Press, p. 472, ISBN 0-8493-0594-2, retrieved 2008-06-27
  4. ^ "450960 Lutetium(III) chloride anhydrous, powder, 99.99% trace metals basis". Sigma-Aldrich. Retrieved 2008-06-27.
  5. ^ "Lutetium chloride". pubchem.ncbi.nlm.nih.gov.
  6. ^ "Lutetium(III) chloride hexahydrate 542075". Sigma-Aldrich. Retrieved 2019-07-24.
  7. ^ Wells A.F. (1984) Structural Inorganic Chemistry 5th edition Oxford Science Publications ISBN 0-19-855370-6
  8. ^ Sgouros, George; Bodei, Lisa; McDevitt, Michael R.; Nedrow, Jessie R. (September 2020). "Radiopharmaceutical therapy in cancer: clinical advances and challenges". Nature Reviews Drug Discovery. 19 (9): 589–608. doi:10.1038/s41573-020-0073-9. ISSN 1474-1784. PMC 7390460.
  9. ^ Vyas, Madhusudan (2021-05-01). "Lutetium-177: a flexible radionuclide therapeutic options". Journal of Nuclear Medicine. 62 (supplement 1): 3039–3039. ISSN 0161-5505.
  10. ^ Dash, Ashutosh; Pillai, Maroor Raghavan Ambikalmajan; Knapp, Furn F. (2015-06-01). "Production of 177Lu for Targeted Radionuclide Therapy: Available Options". Nuclear Medicine and Molecular Imaging. 49 (2): 85–107. doi:10.1007/s13139-014-0315-z. ISSN 1869-3482. PMC 4463871. PMID 26085854.
  11. ^ Vogel, W. V.; van der Marck, S. C.; Versleijen, M. W. J. (2021-07-01). "Challenges and future options for the production of lutetium-177". European Journal of Nuclear Medicine and Molecular Imaging. 48 (8): 2329–2335. doi:10.1007/s00259-021-05392-2. ISSN 1619-7089. PMC 8241800. PMID 33974091.
  12. ^ Das, Tapas; Banerjee, Sharmila (2016). "Theranostic Applications of Lutetium-177 in Radionuclide Therapy". Current Radiopharmaceuticals. 9 (1): 94–101. doi:10.2174/1874471008666150313114644. ISSN 1874-4729. PMID 25771364.
  13. ^ Patnaik, Pradyot (2004), Handbook of Inorganic Chemicals, Amsterdam: McGraw-Hill Professional, p. 244, ISBN 0-07-049439-8, retrieved 2008-06-27
Retrieved from "https://wiki.riteme.site/w/index.php?title=Lutetium(III)_chloride&oldid=1247293645"