Ljiljana Paša-Tolić

Ljiljana Paša-Tolić
Alma mater	University of Zagreb
Scientific career
Fields	Mass spectrometry Proteomics Metabolomics
Institutions	Pacific Northwest National Laboratory National High Magnetic Field Laboratory
Thesis	(1992)
Website	www.pnnl.gov/science/staff/staff_info.asp?staff_num=5883

Ljiljana Paša-Tolić is a Croatian research scientist who is a research fellow in Functional and Systems Biology at the Pacific Northwest National Laboratory. She is responsible for developing capability in mass spectrometry at the PNNL Environmental Molecular Sciences Laboratory. Her research looks to develop analytical techniques to modify protein abundance.

Early life and education

Paša-Tolić studied chemistry at the University of Zagreb. She remained in Zagreb for graduate research, specializing in physical organic chemistry.

Research and career

She completed post-doctoral research at the National High Magnetic Field Laboratory under the direction of Alan G. Marshall. She developed a fourier-transform ion cyclotron resonance spectrometer to study biopolymers. She then moved to the PNNL as a postdoctoral fellow in Richard D. Smith's laboratory in1995.

Paša-Tolić is an expert in mass spectrometry and the development of analytical methods to understand molecular processes. She developed sophisticated modalities of mass spectrometry to investigate the polymerases found in plants. Her research showed that the polymerases found in Arabidopsis are actually derivatives of a polymerase found in eukaryotes.

Paša-Tolić was included in the 2021 and 2024 Analytical Scientist Power List. She received the Jochen Franzen Award from the International Mass Spectrometry Foundation in 2024, for "outstanding contributions to innovations in structural, spatial and/or separation analysis with mass spectrometry”.

Selected publications

Her publications include:

• Susan M Varnum; Daniel N Streblow; Matthew E Monroe; et al. (1 October 2004). "Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome". Journal of Virology. 78 (20): 10960–10966. doi:10.1128/JVI.78.20.10960-10966.2004. ISSN 0022-538X. PMC 521840. PMID 15452216. Wikidata Q37568012.
• Richard D. Smith; Gordon A. Anderson; Mary S. Lipton; Ljiljana Pasa-Tolic; Yufeng Shen; Thomas P. Conrads; Timothy D. Veenstra; Harold R. Udseth (May 2002). "An accurate mass tag strategy for quantitative and high-throughput proteome measurements". Proteomics. 2 (5): 513–523. doi:10.1002/1615-9861(200205)2:5<513::AID-PROT513>3.0.CO;2-W. ISSN 1615-9853. PMID 11987125. Wikidata Q58069136.
• Mary S Lipton; Ljiljana Pasa-Tolic'; Gordon A Anderson; et al. (20 August 2002). "Global analysis of the Deinococcus radiodurans proteome by using accurate mass tags". Proceedings of the National Academy of Sciences of the United States of America. 99 (17): 11049–54. Bibcode:2002PNAS...9911049L. doi:10.1073/PNAS.172170199. ISSN 0027-8424. PMC 129300. PMID 12177431. Wikidata Q24535537.