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Protein-coding gene in the species Homo sapiens
U6 snRNA-associated Sm-like protein LSm4 is a protein that in humans is encoded by the LSM4 gene .[ 5] [ 6] [ 7]
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM][ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000130520 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031848 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
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^ Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro" . EMBO J . 18 (20): 5789–802. doi :10.1093/emboj/18.20.5789 . PMC 1171645 . PMID 10523320 .
^ a b "Entrez Gene: LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)" .
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