LSM10

LSM10
Identifiers
Aliases	LSM10, MST074, MSTP074, U7 small nuclear RNA associated
External IDs	OMIM: 617909; MGI: 2151045; HomoloGene: 13154; GeneCards: LSM10; OMA:LSM10 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	36,397,908 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	125,992,377 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; granulocyte; ; apex of heart; ; monocyte; ; right auricle; ; skeletal muscle tissue; ; tibialis anterior muscle; ; quadriceps femoris muscle; ; muscle layer of sigmoid colon;
	Top expressed in
	interventricular septum; ; primary oocyte; ; granulocyte; ; endocardial cushion; ; yolk sac; ; right kidney; ; medial ganglionic eminence; ; left lobe of liver; ; embryo; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	U7 snRNA binding; protein binding; histone pre-mRNA DCP binding; RNA binding;
Cellular component	Cajal body; U7 snRNP; nucleus; nucleoplasm; nuclear body;
Biological process	positive regulation of G1/S transition of mitotic cell cycle; termination of RNA polymerase II transcription; mRNA processing; histone mRNA metabolic process; RNA splicing;
	Sources:Amigo / QuickGO
Orthologs
	84967
	116748
	ENSG00000181817
	ENSMUSG00000050188
	Q969L4
	Q8QZX5
	NM_032881
	NM_001163266; NM_138721
	NP_116270
	NP_001156738; NP_620046
	Wikidata
View/Edit Human	View/Edit Mouse

U7 snRNA-associated Sm-like protein LSm10 is a protein that in humans is encoded by the LSM10 gene.^[5]^[6]

Interactions

LSM10 has been shown to interact with LSM3.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181817 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050188 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pillai RS, Will CL, Lührmann R, Schümperli D, Müller B (Oct 2001). "Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein" (PDF). The EMBO Journal. 20 (19): 5470–9. doi:10.1093/emboj/20.19.5470. PMC 125645. PMID 11574479.
^ "Entrez Gene: LSM10 LSM10, U7 small nuclear RNA associated".
^ Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Dominski Z, Zheng LX, Sanchez R, Marzluff WF (May 1999). "Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA". Molecular and Cellular Biology. 19 (5): 3561–70. doi:10.1128/mcb.19.5.3561. PMC 84148. PMID 10207079.
Dominski Z, Erkmann JA, Yang X, Sànchez R, Marzluff WF (Jan 2002). "A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing". Genes & Development. 16 (1): 58–71. doi:10.1101/gad.932302. PMC 155312. PMID 11782445.
Pillai RS, Grimmler M, Meister G, Will CL, Lührmann R, Fischer U, Schümperli D (Sep 2003). "Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing". Genes & Development. 17 (18): 2321–33. doi:10.1101/gad.274403. PMC 196468. PMID 12975319.
Hassel S, Eichner A, Yakymovych M, Hellman U, Knaus P, Souchelnytskyi S (May 2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics. 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402. S2CID 6773754.
Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Azzouz TN, Pillai RS, Däpp C, Chari A, Meister G, Kambach C, Fischer U, Schümperli D (Oct 2005). "Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes". The Journal of Biological Chemistry. 280 (41): 34435–40. doi:10.1074/jbc.M505077200. hdl:21.11116/0000-0007-E5F1-6. PMID 16087681.
Wagner EJ, Marzluff WF (Sep 2006). "ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase". Molecular and Cellular Biology. 26 (17): 6702–12. doi:10.1128/MCB.00391-06. PMC 1592837. PMID 16914750.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181817 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050188 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11574479-5] Pillai RS, Will CL, Lührmann R, Schümperli D, Müller B (Oct 2001). "Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein" (PDF). The EMBO Journal. 20 (19): 5470–9. doi:10.1093/emboj/20.19.5470. PMC 125645. PMID 11574479.

[entrez-6] "Entrez Gene: LSM10 LSM10, U7 small nuclear RNA associated".

[pmid15231747-7] Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.

[pmid16189514-8] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[2]

[3]

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[5]

[6]

[7]

[8]

LSM10

Interactions

See also

References

Further reading