LMO7

LMO7
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2EAQ
Identifiers
Aliases	LMO7, FBX20, FBXO20, LOMP, LIM domain 7, LMO7b
External IDs	OMIM: 604362; MGI: 1353586; HomoloGene: 83924; GeneCards: LMO7; OMA:LMO7 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) Band 13q22.2 Start 75,620,434 bp End 75,859,870 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14 E2.3|14 50.9 cM Start 101,729,957 bp End 101,934,710 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve apex of heart right lung upper lobe of left lung right auricle Achilles tendon left lobe of thyroid gland right lobe of thyroid gland olfactory zone of nasal mucosa stromal cell of endometrium Top expressed in zygote secondary oocyte Ileal epithelium cardiac muscle tissue of left ventricle primary oocyte corneal stroma interventricular septum left lung lobe conjunctival fornix right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding ubiquitin-protein transferase activity DNA-binding transcription factor activity Cellular component cytoplasm ubiquitin ligase complex nucleus focal adhesion cytosol nuclear envelope cell surface apical plasma membrane Biological process regulation of cell adhesion protein ubiquitination regulation of signaling protein polyubiquitination post-translational protein modification positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4008 380928 Ensembl ENSG00000136153 ENSMUSG00000033060 UniProt Q8WWI1 n/a RefSeq (mRNA) NM_001306080 NM_005358 NM_015842 NM_015843 NM_001330583 NM_201529 NM_001347628 RefSeq (protein) NP_001293009 NP_001317512 NP_005349 NP_056667 NP_001353561 NP_001353562 NP_001353563 NP_001353565 NP_001293009.1 n/a Location (UCSC) Chr 13: 75.62 – 75.86 Mb Chr 14: 101.73 – 101.93 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

LIM domain only protein 7 is a protein that in humans is encoded by the LMO7 gene.

This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain. An F-box (FBX) domain is present in alternative splice variants. Members of the LIM protein family carry the LIM domain, a unique cysteine-rich zinc-binding domain. Members of the FBX protein family are involved in protein-protein interactions. The encoded protein may be involved in protein-protein interactions. Multiple alternative splice variants have been described but their full-length sequences have not been determined.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Rozenblum E, Vahteristo P, Sandberg T, et al. (2002). "A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes". Hum. Genet. 110 (2): 111–21. doi:10.1007/s00439-001-0646-6. PMID 11935316. S2CID 21371347.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Kim J, Bhinge AA, Morgan XC, Iyer VR (2005). "Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment". Nat. Methods. 2 (1): 47–53. doi:10.1038/nmeth726. PMID 15782160. S2CID 6135437.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
• Iwabuchi K, Kaneko T, Kikuyama M (2006). "Ionic mechanism of mechano-perception in Characeae". Plant Cell Physiol. 46 (11): 1863–71. doi:10.1093/pcp/pci204. PMID 16192285.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Holaska JM, Rais-Bahrami S, Wilson KL (2007). "Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes". Hum. Mol. Genet. 15 (23): 3459–72. doi:10.1093/hmg/ddl423. PMID 17067998.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.