LIN7C

LIN7C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LRA
Identifiers
Aliases	LIN7C, LIN-7-C, LIN-7C, MALS-3, MALS3, VELI3, lin-7 homolog C, crumbs cell polarity complex component
External IDs	OMIM: 612332; MGI: 1330839; HomoloGene: 22649; GeneCards: LIN7C; OMA:LIN7C - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	27,506,769 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	109,731,348 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; germinal epithelium; ; epithelium of nasopharynx; ; retinal pigment epithelium; ; tibia; ; oral cavity; ; Brodmann area 23; ; visceral pleura; ; parietal pleura; ; kidney tubule;
	Top expressed in
	olfactory epithelium; ; lobe of cerebellum; ; medial ganglionic eminence; ; median eminence; ; pineal gland; ; cerebellar vermis; ; zygote; ; tail of embryo; ; dentate gyrus; ; superior cervical ganglion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; cytoskeletal protein binding; L27 domain binding; PDZ domain binding;
Cellular component	cytoplasm; postsynaptic membrane; postsynaptic density; membrane; cell-cell junction; bicellular tight junction; plasma membrane; MPP7-DLG1-LIN7 complex; cell junction; basolateral plasma membrane; neuron projection; presynapse; synapse; glutamatergic synapse;
Biological process	protein localization to basolateral plasma membrane; maintenance of epithelial cell apical/basal polarity; protein transport; morphogenesis of an epithelial sheet; neurotransmitter secretion; exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	55327
	22343
	ENSG00000148943
	ENSMUSG00000027162
	Q9NUP9
	O88952
	NM_018362
	NM_011699
	NP_060832
	NP_035829
	Wikidata
View/Edit Human	View/Edit Mouse

Lin-7 homolog C is a protein that in humans is encoded by the LIN7C gene.^[5]^[6]

Interactions

LIN7C has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148943 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027162 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi:10.1523/JNEUROSCI.19-11-04189.1999. PMC 6782594. PMID 10341223.
^ "Entrez Gene: LIN7C lin-7 homolog C (C. elegans)".
^ ^a ^b ^c Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
^ ^a ^b Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bécamel C, Alonso G, Galéotti N, Demey E, Jouin P, Ullmer C, Dumuis A, Bockaert J, Marin P (2002). "Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach". EMBO J. 21 (10): 2332–42. doi:10.1093/emboj/21.10.2332. PMC 126011. PMID 12006486.
Hori K, Konno D, Maruoka H, Sobue K (2003). "MALS is a binding partner of IRSp53 at cell-cell contacts". FEBS Lett. 554 (1–2): 30–4. Bibcode:2003FEBSL.554...30H. doi:10.1016/S0014-5793(03)01074-3. PMID 14596909. S2CID 30329043.
Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
Petrosky KY, Ou HD, Löhr F, Dötsch V, Lim WA (2006). "A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes". J. Biol. Chem. 280 (46): 38528–36. doi:10.1074/jbc.M506536200. PMID 16147993.
Mendes CC, Gomes DA, Thompson M, Souto NC, Goes TS, Goes AM, Rodrigues MA, Gomez MV, Nathanson MH, Leite MF (2006). "The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria". J. Biol. Chem. 280 (49): 40892–900. doi:10.1074/jbc.M506623200. PMID 16192275.
Bohl J, Brimer N, Lyons C, Vande Pol SB (2007). "The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions". J. Biol. Chem. 282 (13): 9392–400. doi:10.1074/jbc.M610002200. PMID 17237226.
Onda T, Uzawa K, Nakashima D, Saito K, Iwadate Y, Seki N, Shibahara T, Tanzawa H (2007). "Lin-7C/VELI3/MALS-3: an essential component in metastasis of human squamous cell carcinoma" (PDF). Cancer Res. 67 (20): 9643–8. doi:10.1158/0008-5472.CAN-07-1911. hdl:10130/633. PMID 17942893.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148943 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027162 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10341223-5] Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi:10.1523/JNEUROSCI.19-11-04189.1999. PMC 6782594. PMID 10341223.

[entrez-6] "Entrez Gene: LIN7C lin-7 homolog C (C. elegans)".

[pmid14960569-7] Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.

[pmid15024025-8] Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.

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Interactions

References

Further reading