LGALS13

LGALS13
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1F87
Identifiers
Aliases	LGALS13, GAL13, PLAC8, PP13, galectin 13
External IDs	OMIM: 608717; HomoloGene: 49329; GeneCards: LGALS13; OMA:LGALS13 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	39,607,474 bp
RNA expression pattern
	Top expressed in
	placenta; ; thymus; ; striated muscle tissue; ; skeletal muscle tissue; ; thigh; ; muscle of thigh; ; cerebellum; ; cerebellar cortex; ; right hemisphere of cerebellum; ; hypothalamus;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	lysophospholipase activity; protein binding; carbohydrate binding;
Cellular component	cytoplasm; nuclear matrix; nucleus;
Biological process	phospholipid metabolic process; positive regulation of T cell apoptotic process; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	29124
	n/a
	ENSG00000105198
	n/a
	Q9UHV8
	n/a
	NM_013268
	n/a
	NP_037400
	n/a
	Wikidata
View/Edit Human

Placental protein 13 (PP13) is a protein that in humans is encoded by the LGALS13 gene.^[3]^[4]

Structure and function

Function

It is composed of two identical subunits which are held together by disulfide bonds. The monomer of this protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family, but it could not bind beta-galactoside. This is because the ligand binding site is lack of key residue for binding beta-galactoside. ^[5]It is a galectin-like protein. The ligand of this protein is still unknown.

Clinical significance

PP13 levels that are low in the first trimester of pregnancy confers a higher risk for developing pre-eclampsia later in pregnancy.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105198 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bohn H, Kraus W, Winckler W (Jul 1983). "Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17)". Oncodevelopmental Biology and Medicine. 4 (5): 343–50. PMID 6856484.
^ Than NG, Sumegi B, Than GN, Berente Z, Bohn H (November 1999). "Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden Crystal protein". Placenta. 20 (8): 703–10. doi:10.1053/plac.1999.0436. PMID 10527825.
^ Su J, Wang Y, Si Y, Gao J, Song C, Cui L, Wu R, Tai G, Zhou Y (January 2018). "Galectin-13, a different prototype galectin, does not bind β-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138". Scientific Reports. 8 (1): 980. Bibcode:2018NatSR...8..980S. doi:10.1038/s41598-018-19465-0. PMC 5772480. PMID 29343868.
^ Huppertz B, Meiri H, Gizurarson S, Osol G, Sammar M (February 2013). "Placental protein 13 (PP13): a new biological target shifting individualized risk assessment to personalized drug design combating pre-eclampsia". Human Reproduction Update. 19 (4): 391–405. doi:10.1093/humupd/dmt003. PMID 23420029.

External links

Overview of all the structural information available in the PDB for UniProt: Q9UHV8 (Human Galactoside-binding soluble lectin 13) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105198 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6856484-3] Bohn H, Kraus W, Winckler W (Jul 1983). "Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17)". Oncodevelopmental Biology and Medicine. 4 (5): 343–50. PMID 6856484.

[pmid10527825-4] Than NG, Sumegi B, Than GN, Berente Z, Bohn H (November 1999). "Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden Crystal protein". Placenta. 20 (8): 703–10. doi:10.1053/plac.1999.0436. PMID 10527825.

[pmid29343868-5] Su J, Wang Y, Si Y, Gao J, Song C, Cui L, Wu R, Tai G, Zhou Y (January 2018). "Galectin-13, a different prototype galectin, does not bind β-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138". Scientific Reports. 8 (1): 980. Bibcode:2018NatSR...8..980S. doi:10.1038/s41598-018-19465-0. PMC 5772480. PMID 29343868.

[pmid23420029-6] Huppertz B, Meiri H, Gizurarson S, Osol G, Sammar M (February 2013). "Placental protein 13 (PP13): a new biological target shifting individualized risk assessment to personalized drug design combating pre-eclampsia". Human Reproduction Update. 19 (4): 391–405. doi:10.1093/humupd/dmt003. PMID 23420029.

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