LDOC1

LDOC1
Identifiers
Aliases	LDOC1, BCUR1, Mar7, Mart7, leucine zipper, down-regulated in cancer 1, regulator of NFKB signaling, SIRH7, RTL7, LDOC1 regulator of NFKB signaling
External IDs	OMIM: 300402; MGI: 2685212; HomoloGene: 32153; GeneCards: LDOC1; OMA:LDOC1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	141,177,129 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	60,754,561 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; ascending aorta; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; anterior pituitary; ; prefrontal cortex; ; left coronary artery; ; right frontal lobe; ; dorsolateral prefrontal cortex;
	Top expressed in
	lumbar subsegment of spinal cord; ; facial motor nucleus; ; embryo; ; embryo; ; blastocyst; ; cerebellar cortex; ; substantia nigra; ; yolk sac; ; anterior horn of spinal cord; ; decidua;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	nucleus; nucleolus;
Biological process	maternal placenta development; maternal process involved in parturition; regulation of growth hormone activity; negative regulation of cell population proliferation; cellular response to lipopolysaccharide; cellular response to muramyl dipeptide;
	Sources:Amigo / QuickGO
Orthologs
	23641
	434784
	ENSG00000182195
	ENSMUSG00000057615
	O95751
	Q7TPY9
	NM_012317
	NM_001018087
	NP_036449
	NP_001018097
	Wikidata
View/Edit Human	View/Edit Mouse

Protein LDOC1 is a protein that in humans is encoded by the LDOC1 gene.^[5]^[6]^[7]^[8]

Function

The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.^[8]

Interactions

LDOC1 has been shown to interact with ABLIM1.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182195 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057615 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagasaki K, Manabe T, Hanzawa H, Maass N, Tsukada T, Yamaguchi K (Jun 1999). "Identification of a novel gene, LDOC1, down-regulated in cancer cell lines". Cancer Letters. 140 (1–2): 227–34. doi:10.1016/S0304-3835(99)00087-7. PMID 10403563.
^ Brandt J, Schrauth S, Veith AM, Froschauer A, Haneke T, Schultheis C, Gessler M, Leimeister C, Volff JN (Jan 2005). "Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals". Gene. 345 (1): 101–11. doi:10.1016/j.gene.2004.11.022. PMID 15716091.
^ Brandt J, Veith AM, Volff JN (Aug 2005). "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes". Cytogenetic and Genome Research. 110 (1–4): 307–17. doi:10.1159/000084963. PMID 16093683. S2CID 38398479.
^ ^a ^b "Entrez Gene: LDOC1 leucine zipper, down-regulated in cancer 1".
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Nagasaki K, Schem C, von Kaisenberg C, Biallek M, Rösel F, Jonat W, Maass N (Jul 2003). "Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis". International Journal of Cancer. 105 (4): 454–8. doi:10.1002/ijc.11122. PMID 12712434.
Chih DY, Park DJ, Gross M, Idos G, Vuong PT, Hirama T, Chumakov AM, Said J, Koeffler HP (Dec 2004). "Protein partners of C/EBPepsilon". Experimental Hematology. 32 (12): 1173–81. doi:10.1016/j.exphem.2004.08.014. PMID 15588942.
Inoue M, Takahashi K, Niide O, Shibata M, Fukuzawa M, Ra C (Jan 2005). "LDOC1, a novel MZF-1-interacting protein, induces apoptosis". FEBS Letters. 579 (3): 604–8. doi:10.1016/j.febslet.2004.12.030. PMID 15670815.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182195 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057615 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10403563-5] Nagasaki K, Manabe T, Hanzawa H, Maass N, Tsukada T, Yamaguchi K (Jun 1999). "Identification of a novel gene, LDOC1, down-regulated in cancer cell lines". Cancer Letters. 140 (1–2): 227–34. doi:10.1016/S0304-3835(99)00087-7. PMID 10403563.

[pmid15716091-6] Brandt J, Schrauth S, Veith AM, Froschauer A, Haneke T, Schultheis C, Gessler M, Leimeister C, Volff JN (Jan 2005). "Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals". Gene. 345 (1): 101–11. doi:10.1016/j.gene.2004.11.022. PMID 15716091.

[pmid16093683-7] Brandt J, Veith AM, Volff JN (Aug 2005). "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes". Cytogenetic and Genome Research. 110 (1–4): 307–17. doi:10.1159/000084963. PMID 16093683. S2CID 38398479.

[entrez-8] "Entrez Gene: LDOC1 leucine zipper, down-regulated in cancer 1".

[pmid16189514-9] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[9]

Function

Interactions

References

Further reading