KLK11

KLK11
Identifiers
Aliases	KLK11, PRSS20, TLSP, kallikrein related peptidase 11
External IDs	OMIM: 604434; MGI: 1929977; HomoloGene: 27048; GeneCards: KLK11; OMA:KLK11 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	51,028,039 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,428,687 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; skin of abdomen; ; skin of arm; ; skin of leg; ; human penis; ; oral cavity; ; mucosa of pharynx; ; vulva; ; cervix epithelium; ; gallbladder;
	Top expressed in
	lip; ; esophagus; ; skin of external ear; ; embryo; ; skin of back; ; embryo; ; genital tubercle; ; umbilical cord; ; skin of abdomen; ; trachea;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; hydrolase activity; serine-type endopeptidase activity;
Cellular component	extracellular region; Golgi apparatus; extracellular exosome; extracellular space; secretory granule;
Biological process	proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	11012
	56538
	ENSG00000167757
	ENSMUSG00000067616
	Q9UBX7
	Q9QYN3
	NM_001136032; NM_001167605; NM_006853; NM_144947
	NM_001177373; NM_019974
	NP_001129504; NP_001161077; NP_006844; NP_659196
	NP_001170844; NP_064358
	Wikidata
View/Edit Human	View/Edit Mouse

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.^[5]^[6]^[7]^[8]^[9]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in two transcript variants encoding two different isoforms which are differentially expressed.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167757 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067616 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yoshida S, Taniguchi M, Suemoto T, Oka T, He X, Shiosaka S (Oct 1998). "cDNA cloning and expression of a novel serine protease, TLSP". Biochim Biophys Acta. 1399 (2–3): 225–8. doi:10.1016/s0167-4781(98)00116-x. PMID 9765601.
^ Yousef GM, Scorilas A, Diamandis EP (Apr 2000). "Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family". Genomics. 63 (1): 88–96. doi:10.1006/geno.1999.6072. PMID 10662548.
^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
^ Diamandis EP, Deperthes D, Lundwall Å (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
^ ^a ^b "Entrez Gene: KLK11 kallikrein-related peptidase 11".

Mitsui S, Yamada T, Okui A, et al. (2000). "A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate". Biochem. Biophys. Res. Commun. 272 (1): 205–11. doi:10.1006/bbrc.2000.2761. PMID 10872828.
Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
Nakamura T, Mitsui S, Okui A, et al. (2002). "Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in prostate cancer cell lines". Prostate. 49 (1): 72–8. doi:10.1002/pros.1119. PMID 11550212. S2CID 21572408.
Diamandis EP, Okui A, Mitsui S, et al. (2002). "Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma". Cancer Res. 62 (1): 295–300. PMID 11782391.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nakamura T, Mitsui S, Okui A, et al. (2003). "Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate". Prostate. 54 (4): 299–305. doi:10.1002/pros.10191. PMID 12539228. S2CID 21482369.
Nakamura T, Stephan C, Scorilas A, et al. (2003). "Quantitative analysis of hippostasin/KLK11 gene expression in cancerous and noncancerous prostatic tissues". Urology. 61 (5): 1042–6. doi:10.1016/S0090-4295(02)02443-3. PMID 12736044.
Borgoño CA, Fracchioli S, Yousef GM, et al. (2003). "Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma". Int. J. Cancer. 106 (4): 605–10. CiteSeerX 10.1.1.623.9575. doi:10.1002/ijc.11296. PMID 12845660. S2CID 13671141.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Shigemasa K, Gu L, Tanimoto H, et al. (2004). "Human kallikrein gene 11 (KLK11) mRNA overexpression is associated with poor prognosis in patients with epithelial ovarian cancer". Clin. Cancer Res. 10 (8): 2766–70. doi:10.1158/1078-0432.CCR-03-0269. PMID 15102682. S2CID 1192794.
Diamandis EP, Borgoño CA, Scorilas A, et al. (2005). "Human kallikrein 11: an indicator of favorable prognosis in ovarian cancer patients". Clin. Biochem. 37 (9): 823–9. doi:10.1016/j.clinbiochem.2004.04.009. PMID 15329323.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stavropoulou P, Gregorakis AK, Plebani M, Scorilas A (2005). "Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer". Clin. Chim. Acta. 357 (2): 190–5. doi:10.1016/j.cccn.2005.03.026. PMID 15893744.
Planque C, Aïnciburu M, Heuzé-Vourc'h N, et al. (2006). "Expression of the human kallikrein genes 10 (KLK10) and 11 (KLK11) in cancerous and non-cancerous lung tissues". Biol. Chem. 387 (6): 783–8. doi:10.1515/BC.2006.098. PMID 16800740. S2CID 6937753.
Mitsui S, Nakamura T, Okui A, et al. (2006). "Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin". FEBS J. 273 (16): 3678–86. doi:10.1111/j.1742-4658.2006.05372.x. PMID 16911518. S2CID 25021929.

External links

The MEROPS online database for peptidases and their inhibitors: S01.257

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167757 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067616 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9765601-5] Yoshida S, Taniguchi M, Suemoto T, Oka T, He X, Shiosaka S (Oct 1998). "cDNA cloning and expression of a novel serine protease, TLSP". Biochim Biophys Acta. 1399 (2–3): 225–8. doi:10.1016/s0167-4781(98)00116-x. PMID 9765601.

[pmid10662548-6] Yousef GM, Scorilas A, Diamandis EP (Apr 2000). "Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family". Genomics. 63 (1): 88–96. doi:10.1006/geno.1999.6072. PMID 10662548.

[pmid16800724-7] Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.

[pmid16800723-8] Diamandis EP, Deperthes D, Lundwall Å (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.

[entrez-9] "Entrez Gene: KLK11 kallikrein-related peptidase 11".

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References

Further reading

External links