Kelch-like protein 1

KLHL1
Identifiers
Aliases	KLHL1, MRP2, kelch like family member 1
External IDs	OMIM: 605332; MGI: 2136335; HomoloGene: 56903; GeneCards: KLHL1; OMA:KLHL1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	70,108,493 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	96,756,538 bp
RNA expression pattern
	Top expressed in
	pars reticulata; ; pars compacta; ; testicle; ; superior vestibular nucleus; ; ventral tegmental area; ; pons; ; hypothalamus; ; islet of Langerhans; ; ganglionic eminence; ; prefrontal cortex;
	Top expressed in
	ventral tegmental area; ; substantia nigra; ; lumbar subsegment of spinal cord; ; lateral hypothalamus; ; habenula; ; ventromedial nucleus; ; mammillary body; ; supraoptic nucleus; ; central gray substance of midbrain; ; medial vestibular nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin-protein transferase activity; actin binding;
Cellular component	Cul3-RING ubiquitin ligase complex; cytoskeleton; dendrite; soma; cytoplasm;
Biological process	cerebellar Purkinje cell layer development; actin cytoskeleton organization; locomotory behavior; adult walking behavior; dendrite development; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	57626
	93688
	ENSG00000150361
	ENSMUSG00000022076
	Q9NR64
	Q9JI74
	NM_020866; NM_001286725
	NM_053105
	NP_001273654; NP_065917
	NP_444335
	Wikidata
View/Edit Human	View/Edit Mouse

Kelch-like protein 1 is a protein that in humans is encoded by the KLHL1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000150361 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022076 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nemes JP, Benzow KA, Moseley ML, Ranum LP, Koob MD (Sep 2000). "The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1)". Hum Mol Genet. 9 (10): 1543–51. doi:10.1093/hmg/9.10.1543. PMID 10888605.
^ "Entrez Gene: KLHL1 kelch-like 1 (Drosophila)".

Aromolaran KA, Benzow KA, Koob MD, Piedras-Rentería ES (2007). "The Kelch-like protein 1 modulates P/Q-type calcium current density". Neuroscience. 145 (3): 841–50. doi:10.1016/j.neuroscience.2006.12.046. PMID 17289272. S2CID 20055866.
Seng S, Avraham HK, Jiang S, et al. (2007). "KLHL1/MRP2 mediates neurite outgrowth in a glycogen synthase kinase 3beta-dependent manner". Mol. Cell. Biol. 26 (22): 8371–84. doi:10.1128/MCB.02167-05. PMC 1636797. PMID 16982692.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000150361 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022076 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10888605-5] Nemes JP, Benzow KA, Moseley ML, Ranum LP, Koob MD (Sep 2000). "The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1)". Hum Mol Genet. 9 (10): 1543–51. doi:10.1093/hmg/9.10.1543. PMID 10888605.

[entrez-6] "Entrez Gene: KLHL1 kelch-like 1 (Drosophila)".

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References

Further reading