IFT74

IFT74
Identifiers
Aliases	IFT74, CCDC2, CMG-1, CMG1, intraflagellar transport 74, BBS20, BBS22, SPGF58, JBTS40
External IDs	OMIM: 608040; MGI: 1914944; HomoloGene: 11831; GeneCards: IFT74; OMA:IFT74 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	27,066,134 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	94,693,229 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; caput epididymis; ; right uterine tube; ; Achilles tendon; ; corpus epididymis; ; left testis; ; right testis; ; testicle; ; gonad; ; mucosa of paranasal sinus;
	Top expressed in
	seminiferous tubule; ; olfactory epithelium; ; spermatid; ; spermatocyte; ; maxillary prominence; ; mandibular prominence; ; saccule; ; Gonadal ridge; ; otic vesicle; ; Epithelium of choroid plexus;
	More reference expression data
	n/a
Gene ontology
Molecular function	chromatin binding; beta-tubulin binding; protein binding;
Cellular component	intraciliary transport particle B; centrosome; cell projection; ciliary tip; motile cilium; cytoplasmic vesicle; nucleus; cilium;
Biological process	Notch signaling pathway; intraciliary transport; heart development; keratinocyte development; determination of left/right symmetry; cell projection organization; epidermis development; negative regulation of epithelial cell proliferation; positive regulation of cell adhesion mediated by integrin; positive regulation of transcription by RNA polymerase II; intraciliary transport involved in cilium assembly; cilium assembly; non-motile cilium assembly;
	Sources:Amigo / QuickGO
Orthologs
	80173
	67694
	ENSG00000096872
	ENSMUSG00000028576
	Q96LB3
	Q8BKE9
	NM_001099222; NM_001099223; NM_001099224; NM_025103; NM_001349928
	NM_001290568; NM_026319
	NP_001092692; NP_001092693; NP_001092694; NP_079379; NP_001336857
	NP_001277497; NP_080595
	Wikidata
View/Edit Human	View/Edit Mouse

Intraflagellar transport protein 74 homolog (IFT74), also known as coiled-coil domain-containing protein 2 (CCDC2) and capillary morphogenesis gene 1 protein (CMG1), is a protein that in humans is encoded by the IFT74 gene.^[5]^[6]

BCMG1 is upregulated by umbilical vein endothelial cells during capillary morphogenesis.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000096872 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028576 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: intraflagellar transport 74 homolog (Chlamydomonas)".
^ ^a ^b Bell SE, Mavila A, Salazar R, Bayless KJ, Kanagala S, Maxwell SA, Davis GE (August 2001). "Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling". J. Cell Sci. 114 (Pt 15): 2755–73. doi:10.1242/jcs.114.15.2755. PMID 11683410.

Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Xiao S, Sato C, Kawarai T, et al. (2008). "Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis". Neurobiol. Aging. 29 (8): 1279–82. doi:10.1016/j.neurobiolaging.2007.02.022. PMID 17383054. S2CID 10392826.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000096872 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028576 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: intraflagellar transport 74 homolog (Chlamydomonas)".

[pmid11683410-6] Bell SE, Mavila A, Salazar R, Bayless KJ, Kanagala S, Maxwell SA, Davis GE (August 2001). "Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling". J. Cell Sci. 114 (Pt 15): 2755–73. doi:10.1242/jcs.114.15.2755. PMID 11683410.

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References

Further reading