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Pyridoxine

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Pyridoxine
Pyridoxine
Clinical data
Other namesvitamin B6, pyridoxol[1] pyridoxine hydrochloride
AHFS/Drugs.comMonograph
License data
Pregnancy
category
Routes of
administration		By mouth, intravenous (IV), intramuscular (IM), subcutaneous
ATC code
Legal status
Legal status
Pharmacokinetic data
Elimination half-lifeseveral weeks (see #Metabolism for details)
Identifiers
  • 4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.548 Edit this at Wikidata
Chemical and physical data
FormulaC8H11NO3
Molar mass169.180 g·mol−1
3D model (JSmol)
Melting point159 to 162 °C (318 to 324 °F)
  • OCc1cnc(C)c(O)c1CO
  • InChI=1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3 checkY
  • Key:LXNHXLLTXMVWPM-UHFFFAOYSA-N

Pyridoxine (PN)[4] is a form of vitamin B6 found commonly in food and used as a dietary supplement. As a supplement it is used to treat and prevent pyridoxine deficiency, sideroblastic anaemia, pyridoxine-dependent epilepsy, certain metabolic disorders, side effects or complications of isoniazid use, and certain types of mushroom poisoning.[5] It is used by mouth or by injection.[5]

It is usually well tolerated.[5] Occasionally side effects include headache, numbness, and sleepiness.[5] Normal doses are safe during pregnancy and breastfeeding.[5] Pyridoxine is in the vitamin B family of vitamins.[5] It is required by the body to metabolise amino acids, carbohydrates, and lipids.[5] Sources in the diet include meat, fish, fruit, vegetables, and grain.[6]

Medical uses

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As a treatment (oral or injection), it is used to treat or prevent pyridoxine deficiency, sideroblastic anaemia, pyridoxine-dependent epilepsy, certain metabolic disorders, side effects of isoniazid treatment and certain types of mushroom poisoning.[5] Isoniazid is an antibiotic used for the treatment of tuberculosis. Common side effect include numbness in the hands and feet.[7] Co-treatment with vitamin B6 alleviates the numbness.[8] Pyridoxine-dependent epilepsy is a type of rare infant epilepsy that does not improve with typical anti-seizure medications.[9]

Pyridoxine in combination with doxylamine is used as a treatment for morning sickness in pregnant women.[10]

Side effects

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It is usually well tolerated, though overdose toxicity is possible.[5] Occasionally side effects include headache, numbness, and sleepiness.[5] Pyridoxine overdose can cause a peripheral sensory neuropathy characterized by poor coordination, numbness, and decreased sensation to touch, temperature, and vibration.[11] Healthy human blood levels of pyridoxine are 2.1–21.7 ng/mL. Normal doses are safe during pregnancy and breastfeeding.[5]

Mechanism

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Pyridoxine is in the vitamin B family of vitamins.[5] It is required by the body to make amino acids, carbohydrates, and lipids.[5] Sources in the diet include fruit, vegetables, and grain.[6] It is also required for muscle phosphorylase activity associated with glycogen metabolism.

Metabolism

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The half-life of pyridoxine varies according to different sources: one source suggests that the half-life of pyridoxine is up to 20 days,[12] while another source indicates half-life of vitamin B6 is in range of 25 to 33 days.[13] After considering the different sources, it can be concluded that the half-life of pyridoxine is typically measured in several weeks.[12][13]

History

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Pyridoxine was discovered in 1934, isolated in 1938, and first made in 1939.[14][15] It is on the World Health Organization's List of Essential Medicines.[16] Pyridoxine is available both as a generic medication and over the counter product.[5] Foods, such as breakfast cereal have pyridoxine added in some countries.[6]

References

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  1. ^ Dryhurst G (2012). "Electrochemistry of Biologically Important Pyridines". Electrochemistry of Biological Molecules. Elsevier. p. 562. ISBN 978-0-323-14452-0. Archived from the original on 30 December 2016.
  2. ^ "Pyridoxine Use During Pregnancy". Drugs.com. 27 April 2020. Archived from the original on 4 December 2020. Retrieved 6 May 2020.
  3. ^ "Pyridoxine 50mg Tablets - Summary of Product Characteristics (SmPC)". (emc). 27 April 2015. Archived from the original on 12 October 2013. Retrieved 6 May 2020.
  4. ^ "Vitamin B-6". iupac.qmul.ac.uk. Retrieved 26 September 2024.
  5. ^ a b c d e f g h i j k l m n "Pyridoxine Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 30 December 2016. Retrieved 8 December 2016.
  6. ^ a b c "Office of Dietary Supplements - Dietary Supplement Fact Sheet: Vitamin B6". ods.od.nih.gov. 11 February 2016. Archived from the original on 12 December 2016. Retrieved 30 December 2016.
  7. ^ "Isoniazid". The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 13 August 2021.
  8. ^ Lheureux P, Penaloza A, Gris M (April 2005). "Pyridoxine in clinical toxicology: a review". European Journal of Emergency Medicine. 12 (2): 78–85. doi:10.1097/00063110-200504000-00007. PMID 15756083. S2CID 39197646.
  9. ^ Abend NS, Loddenkemper T (July 2014). "Management of pediatric status epilepticus". Current Treatment Options in Neurology. 16 (7): 301. doi:10.1007/s11940-014-0301-x. PMC 4110742. PMID 24909106.
  10. ^ Anh NH, Kim SJ, Long NP, Min JE, Yoon YC, Lee EG, et al. (January 2020). "Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials". Nutrients. 12 (1): 157. doi:10.3390/nu12010157. PMC 7019938. PMID 31935866.
  11. ^ "Pyridoxine deficiency and toxicity". MedLink Neurology. www.medlink.com. Archived from the original on 19 July 2020. Retrieved 14 December 2020.
  12. ^ a b Kennedy A, Schaeffer T (2016). "Pyridoxine". Critical Care Toxicology. pp. 1–4. doi:10.1007/978-3-319-20790-2_174-1. ISBN 978-3-319-20790-2. The half-life of pyridoxine is up to 20 days.
  13. ^ a b Assessment of vitamin B6 intake in relation to tolerable upper intake levels. Opinion of the Panel on Nutrition, Dietetic Products, Novel Food and Allergy of the Norwegian Scientific Committee for Food Safety (PDF). Oslo, Norway. ISBN 978-82-8259-260-4. Archived from the original (PDF) on 17 November 2019. Retrieved 7 December 2019. Eighty to ninety percent of vitamin B6 in the body is found in muscles and estimated body stores in adults amount to about 170 mg with a half-life of 25-33 days.
  14. ^ Squires VR (2011). The Role of Food, Agriculture, Forestry and Fisheries in Human Nutrition - Volume IV. EOLSS Publications. p. 121. ISBN 978-1-84826-195-2. Archived from the original on 11 January 2023. Retrieved 30 June 2020.
  15. ^ Harris H (2012). Advances in Human Genetics 6. Springer Science & Business Media. p. 39. ISBN 978-1-4615-8264-9. Archived from the original on 14 January 2023. Retrieved 30 June 2020.
  16. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
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