Hydroxetamine

Hydroxetamine
Legal status
Legal status	CA: HXE is not specifically scheduled but ketamine and its analogues are schedule I; DE: NpSG (Industrial and scientific use only); UK: Class B;
Identifiers
	IUPAC name 2-(ethylamino)-2-(3-hydroxyphenyl)cyclohexan-1-one;
CAS Number	1620054-73-0;
PubChem CID	163192347;
ChemSpider	112747181;
CompTox Dashboard (EPA)	DTXSID001336931 ;
Chemical and physical data
Formula	C14H19NO2
Molar mass	233.311 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1CCCCC1(NCC)C2=CC(O)=CC=C2;
	InChI InChI=1S/C14H19NO2/c1-2-15-14(9-4-3-8-13(14)17)11-6-5-7-12(16)10-11/h5-7,10,15-16H,2-4,8-9H2,1H3; Key:CQERUJSORROCGH-UHFFFAOYSA-N;

Hydroxetamine (3'-hydroxy-2-oxo-PCE, O-desmethylmethoxetamine, HXE) is a recreational designer drug from the arylcyclohexylamine family, with dissociative effects. It is known as an active metabolite of the dissociative designer drug methoxetamine,^[1]^[2] but has also been sold in its own right since late 2019.^[3]

References

^ Menzies EL, Hudson SC, Dargan PI, Parkin MC, Wood DM, Kicman AT (June 2014). "Characterizing metabolites and potential metabolic pathways for the novel psychoactive substance methoxetamine". Drug Testing and Analysis. 6 (6): 506–15. doi:10.1002/dta.1541. PMID 24574323.
^ Horsley RR, Lhotkova E, Hajkova K, Jurasek B, Kuchar M, Palenicek T (September 2016). "Detailed pharmacological evaluation of methoxetamine (MXE), a novel psychoactive ketamine analogue-Behavioural, pharmacokinetic and metabolic studies in the Wistar rat". Brain Research Bulletin. 126 (Pt 1): 102–110. doi:10.1016/j.brainresbull.2016.05.002. PMID 27155360. S2CID 3955788.
^ Alert from NDEWS Web Monitoring Team: Increases in Reddit discussions of HXE in February-May of 2021. National Drug Early Warning System, Issue 39, 11 June 2021. University of Florida, funded by the National Institute on Drug Abuse

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[1] Menzies EL, Hudson SC, Dargan PI, Parkin MC, Wood DM, Kicman AT (June 2014). "Characterizing metabolites and potential metabolic pathways for the novel psychoactive substance methoxetamine". Drug Testing and Analysis. 6 (6): 506–15. doi:10.1002/dta.1541. PMID 24574323.

[2] Horsley RR, Lhotkova E, Hajkova K, Jurasek B, Kuchar M, Palenicek T (September 2016). "Detailed pharmacological evaluation of methoxetamine (MXE), a novel psychoactive ketamine analogue-Behavioural, pharmacokinetic and metabolic studies in the Wistar rat". Brain Research Bulletin. 126 (Pt 1): 102–110. doi:10.1016/j.brainresbull.2016.05.002. PMID 27155360. S2CID 3955788.

[3] Alert from NDEWS Web Monitoring Team: Increases in Reddit discussions of HXE in February-May of 2021. National Drug Early Warning System, Issue 39, 11 June 2021. University of Florida, funded by the National Institute on Drug Abuse

[1]

[2]

[3]

See also

References