Jump to content

HOOK2

From Wikipedia, the free encyclopedia
(Redirected from HOOK2 (gene))
HOOK2
Identifiers
AliasesHOOK2, HK2, hook microtubule-tethering protein 2, hook microtubule tethering protein 2
External IDsOMIM: 607824; MGI: 2181664; HomoloGene: 8332; GeneCards: HOOK2; OMA:HOOK2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001100176
NM_013312

NM_001167991
NM_133255
NM_001363497
NM_001363498

RefSeq (protein)

NP_001093646
NP_037444

Location (UCSC)Chr 19: 12.76 – 12.87 MbChr 8: 84.99 – 85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein Hook homolog 2 (HK2) is a protein[5] that in humans is encoded by the HOOK2 gene.[6][7]

Function

[edit]

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[7]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000095066Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052566Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Krämer H, Phistry M (February 1999). "Genetic analysis of hook, a gene required for endocytic trafficking in drosophila". Genetics. 151 (2): 675–84. doi:10.1093/genetics/151.2.675. PMC 1460498. PMID 9927460.
  6. ^ Walenta JH, Didier AJ, Liu X, Krämer H (March 2001). "The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins". J. Cell Biol. 152 (5): 923–34. doi:10.1083/jcb.152.5.923. PMC 2198811. PMID 11238449.
  7. ^ a b "Entrez Gene: hook homolog 2 (Drosophila)".

Further reading

[edit]