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Gary H. Posner

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Gary H. Posner (June 2, 1943[1] – February 26, 2018[2]) was Scowe Professor of Chemistry at Johns Hopkins University in Baltimore, Maryland.[3] Posner is known for his pioneering research in organocopper chemistry, including his involvement in the development of the Corey–House–Posner–Whitesides reaction.

Career

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Posner was born in New York City[1] and completed his undergraduate studies at Brandeis University. He received his PhD from Harvard University in 1968 where his adviser was E. J. Corey. He did a post-doctoral fellowship at the University of California Berkeley. He was at Johns Hopkins University from 1969 to 2016, where he held the Scowe Professorship in Chemistry from 1989 onwards.

Research

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Posner was first known for his pioneering research in organocopper chemistry in which he developed novel methods for organic synthesis involving organocopper reagents.[4][5] He is the author of the textbook An Introduction to Synthesis Using Organocopper Reagents. Posner has also contributed numerous other developments in synthetic organic chemistry including asymmetric synthesis and multicomponent organic reactions.[6] Posner's recent research has been focused on applying organic synthesis to the preparation of novel medicinal agents including isothiocyanates with anticancer properties,[7] new vitamin D analogs for the treatment of psoriasis,[8][9] and new antimalarial peroxides.[10][11][12]

Awards

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In 1987, Posner was named Maryland Chemist of the Year and in 1994 he received the Distinguished Teaching Award at Johns Hopkins.[3] He was also a 2004 recipient of a Cope Senior Scholar Award from the American Chemical Society.[13]

References

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  1. ^ a b "GARY H. POSNER". The Robert A. Welch Foundation Research Bulletin (46): 18. 1983.
  2. ^ Renowned chemist, longtime Hopkins faculty member Gary Posner dies at 74
  3. ^ a b Jean and Norman Scowe Professorship in Chemistry
  4. ^ Posner, Gary H. (1972). "Conjugate Addition Reactions of Organocopper Reagents". Organic Reactions. Vol. 19. pp. 1–113. doi:10.1002/0471264180.or019.01. ISBN 978-0471264187.
  5. ^ Posner, Gary H. (1975). "Substitution Reactions Using Organocopper Reagents". Organic Reactions. Vol. 22. pp. 253–400. doi:10.1002/0471264180.or022.02. ISBN 978-0471264187.
  6. ^ Posner, Gary H.; Canella, Karen A.; Silversmith, Ernest F. (1988). "One-pot, three-component, sequential Michael-Michael-ring-closure reactions. Annulation of meta-dicarboxylated aromatic rings. Total synthesis of juncunol". Journal of Chemical Sciences. 100 (2–3): 81–90. doi:10.1007/BF02839442. S2CID 91965184.
  7. ^ Posner, Gary H.; Cho, C.-G.; Green, Julianne V.; Zhang, Yuesheng; Talalay, Paul (1994). "Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes". Journal of Medicinal Chemistry. 37 (1): 170–6. doi:10.1021/jm00027a021. PMID 8289191.
  8. ^ Posner, G; Kahraman, M (2005). Overview: rational design of 1α,25-dihydroxyvitamin D3 analogs (Deltanoids). Vol. 2. pp. 1405–1422. doi:10.1016/B978-012252687-9/50084-X. ISBN 978-0-12-252687-9. {{cite book}}: |journal= ignored (help)
  9. ^ Guyton, Kathryn Z.; Kensler, Thomas W.; Posner, Gary H. (2004). "Chemopreventive Efficacy of Natural Vitamin D and Synthetic Analogs". Cancer Chemoprevention. Vol. 1. pp. 259–274. doi:10.1007/978-1-59259-767-3_17. ISBN 978-1-61737-342-8.
  10. ^ O'Neill, Paul M.; Posner, Gary H. (2004). "A Medicinal Chemistry Perspective on Artemisinin and Related Endoperoxides". Journal of Medicinal Chemistry. 47 (12): 2945–2964. doi:10.1021/jm030571c. PMID 15163175.
  11. ^ Posner, Gary H.; Parker, Michael H.; Northrop, John; Elias, Jeffrey S.; Ploypradith, Poonsakdi; Xie, Suji; Shapiro, Theresa A. (1999). "Orally Active, Hydrolytically Stable, Semisynthetic, Antimalarial Trioxanes in the Artemisinin Family". Journal of Medicinal Chemistry. 42 (2): 300–304. doi:10.1021/jm980529v. PMID 9925735.
  12. ^ Posner, Gary H.; Paik, Ik-Hyeon; Chang, Wonsuk; Borstnik, Kristina; Sinishtaj, Sandra; Rosenthal, Andrew S.; Shapiro, Theresa A. (2007). "Malaria-Infected Mice Are Cured by a Single Dose of Novel Artemisinin Derivatives". Journal of Medicinal Chemistry. 50 (10): 2516–9. doi:10.1021/jm070149m. PMID 17439113.
  13. ^ Arthur C. Cope Scholar Awards Archived 2011-08-11 at the Wayback Machine, American Chemical Society
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  • Seeman, Jeffrey I. (2016). "Gary H. Posner: Professor, Scientist, Colleague, Role Model, and Friend". Tetrahedron. 72 (40): 5950–5955. doi:10.1016/j.tet.2016.06.053.
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