GPRC5C

GPRC5C
Identifiers
Aliases	GPRC5C, RAIG-3, RAIG3, G protein-coupled receptor class C group 5 member C
External IDs	OMIM: 605949; MGI: 1917605; HomoloGene: 11099; GeneCards: GPRC5C; OMA:GPRC5C - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	74,451,653 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	114,763,443 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; olfactory zone of nasal mucosa; ; mucosa of transverse colon; ; right lobe of thyroid gland; ; cerebellar hemisphere; ; left lobe of thyroid gland; ; right hemisphere of cerebellum; ; body of pancreas; ; body of stomach; ; popliteal artery;
	Top expressed in
	lumbar spinal ganglion; ; right kidney; ; genital tubercle; ; tail of embryo; ; proximal tubule; ; inner renal medulla; ; zygote; ; yolk sac; ; muscle of thigh; ; human kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; protein kinase activator activity;
Cellular component	integral component of membrane; vesicle; receptor complex; plasma membrane; integral component of plasma membrane; extracellular exosome; cytoplasmic vesicle membrane; membrane; cytoplasmic vesicle; intracellular membrane-bounded organelle;
Biological process	G protein-coupled receptor signaling pathway; signal transduction; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	55890
	70355
	ENSG00000170412
	ENSMUSG00000051043
	Q9NQ84
	Q8K3J9
	NM_018653; NM_022036; NM_001366261; NM_001366262
	NM_001110337; NM_001110338; NM_147217
	NP_061123; NP_071319; NP_001353190; NP_001353191
	NP_001103807; NP_001103808; NP_671750
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor family C group 5 member C is a protein that in humans is encoded by the GPRC5C gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170412 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051043 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (Nov 2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics. 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.
^ ^a ^b "Entrez Gene: GPRC5C G protein-coupled receptor, family C, group 5, member C".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics. 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.
Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (2001). "Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D". Biochim. Biophys. Acta. 1518 (3): 237–48. doi:10.1016/s0167-4781(01)00197-x. PMID 11311935.
Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170412 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051043 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10945465-5] Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (Nov 2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics. 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.

[entrez-6] "Entrez Gene: GPRC5C G protein-coupled receptor, family C, group 5, member C".

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GPRC5C

Function

See also

References

Further reading