GPR34

GPR34
Identifiers
Aliases	GPR34, LYPSR1, G protein-coupled receptor 34
External IDs	OMIM: 300241; MGI: 1346334; HomoloGene: 36174; GeneCards: GPR34; OMA:GPR34 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	41,697,275 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	13,507,097 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; smooth muscle tissue; ; testicle; ; placenta; ; mucosa of ileum; ; right coronary artery; ; appendix; ; gallbladder; ; rectum; ; monocyte;
	Top expressed in
	lumbar subsegment of spinal cord; ; stroma of bone marrow; ; dentate gyrus of hippocampal formation granule cell; ; mesenteric lymph nodes; ; Region I of hippocampus proper; ; superior frontal gyrus; ; primary visual cortex; ; spleen; ; ankle; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled purinergic nucleotide receptor activity; G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction; G protein-coupled purinergic nucleotide receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2857
	23890
	ENSG00000171659
	ENSMUSG00000040229
	Q9UPC5
	Q9R1K6
	NM_001033513; NM_001033514; NM_001097579; NM_005300
	NM_011823
	NP_001091048; NP_005291
	NP_035953
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 34 is a protein that in humans is encoded by the GPR34 gene.^[5]^[6]^[7] The receptor binds to lysophosphatidylserine. ^[8]

Function

G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171659 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040229 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schöneberg T, Schulz A, Grosse R, Schade R, Henklein P, Schultz G, Gudermann T (July 1999). "A novel subgroup of class I G-protein-coupled receptors". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1446 (1–2): 57–70. doi:10.1016/s0167-4781(99)00081-0. PMID 10395919.
^ Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (February 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno.1998.5655. PMID 10036181.
^ ^a ^b "Entrez Gene: GPR34 G protein-coupled receptor 34".
^ Sugo T, Tachimoto H, Chikatsu T, Murakami Y, Kikukawa Y, Sato S; et al. (2006). "Identification of a lysophosphatidylserine receptor on mast cells". Biochem Biophys Res Commun. 341 (4): 1078–87. doi:10.1016/j.bbrc.2006.01.069. PMID 16460680.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Jacobi FK, Broghammer M, Pesch K, Zrenner E, Berger W, Meindl A, Pusch CM (July 2000). "Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1". Human Genetics. 107 (1): 89–91. doi:10.1007/s004390050017. PMID 10982042.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Engemaier E, Römpler H, Schöneberg T, Schulz A (February 2006). "Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34". Genomics. 87 (2): 254–64. doi:10.1016/j.ygeno.2005.10.001. PMID 16338117.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (December 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Liebscher I, Müller U, Teupser D, Engemaier E, Engel KM, Ritscher L, Thor D, Sangkuhl K, Ricken A, Wurm A, Piehler D, Schmutzler S, Fuhrmann H, Albert FW, Reichenbach A, Thiery J, Schöneberg T, Schulz A (January 2011). "Altered immune response in mice deficient for the G protein-coupled receptor GPR34". The Journal of Biological Chemistry. 286 (3): 2101–10. doi:10.1074/jbc.M110.196659. PMC 3023507. PMID 21097509.
Ritscher L, Engemaier E, Stäubert C, Liebscher I, Schmidt P, Hermsdorf T, Römpler H, Schulz A, Schöneberg T (May 2012). "The ligand specificity of the G-protein-coupled receptor GPR34". The Biochemical Journal. 443 (3): 841–50. doi:10.1042/BJ20112090. PMID 22348703.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171659 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040229 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10395919-5] Schöneberg T, Schulz A, Grosse R, Schade R, Henklein P, Schultz G, Gudermann T (July 1999). "A novel subgroup of class I G-protein-coupled receptors". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1446 (1–2): 57–70. doi:10.1016/s0167-4781(99)00081-0. PMID 10395919.

[pmid10036181-6] Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (February 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno.1998.5655. PMID 10036181.

[entrez-7] "Entrez Gene: GPR34 G protein-coupled receptor 34".

[pmid16460680-8] Sugo T, Tachimoto H, Chikatsu T, Murakami Y, Kikukawa Y, Sato S; et al. (2006). "Identification of a lysophosphatidylserine receptor on mast cells". Biochem Biophys Res Commun. 341 (4): 1078–87. doi:10.1016/j.bbrc.2006.01.069. PMID 16460680.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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Function

References

Further reading