GPR114

ADGRG5
Identifiers
Aliases	ADGRG5, PGR27, GPR114, adhesion G protein-coupled receptor G5
External IDs	OMIM: 616965; MGI: 2685955; HomoloGene: 17828; GeneCards: ADGRG5; OMA:ADGRG5 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	57,591,681 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	95,669,908 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; lymph node; ; blood; ; testicle; ; islet of Langerhans; ; spleen; ; bone marrow cells; ; appendix; ; epithelium of nasopharynx; ; tonsil;
	Top expressed in
	mesenteric lymph nodes; ; secondary oocyte; ; primary oocyte; ; spleen; ; embryo; ; thymus; ; jejunum; ; zygote; ; blood; ; subcutaneous adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; membrane; plasma membrane; intracellular anatomical structure; integral component of plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; signal transduction; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	221188
	382045
	ENSG00000159618
	ENSMUSG00000061577
	Q8IZF4
	Q3V3Z3
	NM_001304376; NM_153837; NM_001318481
	NM_001033468; NM_001145972
	NP_001291305; NP_001305410; NP_722579
	NP_001028640; NP_001139444
	Wikidata
View/Edit Human	View/Edit Mouse

G protein-coupled receptor 114 is a protein encoded by the ADGRG5 gene.^[5]^[6]^[7] GPR114 is a member of the adhesion GPCR family.^[8]^[9] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[10]

Tissue distribution

GPR114 mRNA is specifically expressed in human eosinophils as well as in mouse lymphocytes, monocytes, macrophage, and dendritic cells.^[11]

Signaling

The cyclic adenosine monophosphate (cAMP) assay in overexpressing HEK293 cells has demonstrated coupling of GPR114 to Gα_s protein.^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159618 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061577 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GPR114 G protein-coupled receptor 114".
^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. Bibcode:2002FEBSL.531..407F. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
^ Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.
^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, et al. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
^ Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X (April 2012). "Signaling property study of adhesion G-protein-coupled receptors". FEBS Letters. 586 (8): 1214–1219. Bibcode:2012FEBSL.586.1214G. doi:10.1016/j.febslet.2012.03.014. PMID 22575658. S2CID 3020230.

External links

Adhesion GPCR consortium

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159618 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061577 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GPR114 G protein-coupled receptor 114".

[pmid12435584-6] Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. Bibcode:2002FEBSL.531..407F. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.

[7] Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.

[isbn1-4419-7912-3-8] Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.

[9] Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.

[pmid22333914-10] Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, et al. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

[11] Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.

[12] Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X (April 2012). "Signaling property study of adhesion G-protein-coupled receptors". FEBS Letters. 586 (8): 1214–1219. Bibcode:2012FEBSL.586.1214G. doi:10.1016/j.febslet.2012.03.014. PMID 22575658. S2CID 3020230.

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