GMEB2

GMEB2
Identifiers
Aliases	GMEB2, P79PIF, PIF79, GMEB-2, glucocorticoid modulatory element binding protein 2
External IDs	OMIM: 607451; MGI: 2652836; HomoloGene: 8228; GeneCards: GMEB2; OMA:GMEB2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	63,627,101 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	180,929,828 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; buccal mucosa cell; ; thymus; ; mucosa of urinary bladder; ; mucosa of ileum; ; pancreatic ductal cell; ; granulocyte; ; right lobe of thyroid gland; ; tibialis anterior muscle; ; blood;
	Top expressed in
	granulocyte; ; hand; ; otolith organ; ; utricle; ; cumulus cell; ; blood; ; medial ganglionic eminence; ; neural layer of retina; ; thymus; ; bone marrow;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; transcription coactivator activity; metal ion binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; cytoplasm; cytosol;
Biological process	regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	26205
	229004
	ENSG00000101216
	ENSMUSG00000038705
	Q9UKD1
	P58929
	NM_012384
	NM_198169
	NP_036516
	NP_937812
	Wikidata
View/Edit Human	View/Edit Mouse

Glucocorticoid modulatory element-binding protein 2 is a protein that in humans is encoded by the GMEB2 gene.^[5]^[6]^[7]

This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101216 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038705 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Christensen J, Cotmore SF, Tattersall P (Nov 1999). "Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites". Mol Cell Biol. 19 (11): 7741–50. doi:10.1128/MCB.19.11.7741. PMC 84824. PMID 10523663.
^ Burnett E, Christensen J, Tattersall P (Dec 2001). "A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters". J Mol Biol. 314 (5): 1029–39. doi:10.1006/jmbi.2000.5198. PMID 11743720.
^ ^a ^b "Entrez Gene: GMEB2 glucocorticoid modulatory element binding protein 2".

Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
Kaul S, Blackford JA, Chen J, et al. (2000). "Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins". Mol. Endocrinol. 14 (7): 1010–27. doi:10.1210/me.14.7.1010. PMID 10894151.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Kaul S, Blackford JA, Cho S, Simons SS (2002). "Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors". J. Biol. Chem. 277 (15): 12541–9. doi:10.1074/jbc.M112330200. PMID 11812797.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101216 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038705 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10523663-5] Christensen J, Cotmore SF, Tattersall P (Nov 1999). "Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites". Mol Cell Biol. 19 (11): 7741–50. doi:10.1128/MCB.19.11.7741. PMC 84824. PMID 10523663.

[pmid11743720-6] Burnett E, Christensen J, Tattersall P (Dec 2001). "A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters". J Mol Biol. 314 (5): 1029–39. doi:10.1006/jmbi.2000.5198. PMID 11743720.

[entrez-7] "Entrez Gene: GMEB2 glucocorticoid modulatory element binding protein 2".

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References

Further reading