GLCE

GLCE
Identifiers
Aliases	GLCE, HSEPI, glucuronic acid epimerase
External IDs	OMIM: 612134; MGI: 2136405; HomoloGene: 14111; GeneCards: GLCE; OMA:GLCE - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	69,272,217 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	62,029,937 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; Achilles tendon; ; ganglionic eminence; ; rectum; ; endothelial cell; ; islet of Langerhans; ; secondary oocyte; ; gonad; ; monocyte;
	Top expressed in
	saccule; ; otic placode; ; primary oocyte; ; secondary oocyte; ; otic vesicle; ; cumulus cell; ; medullary collecting duct; ; nucleus accumbens; ; genital tubercle; ; Gonadal ridge;
	More reference expression data
	n/a
Gene ontology
Molecular function	racemase and epimerase activity, acting on carbohydrates and derivatives; isomerase activity; heparosan-N-sulfate-glucuronate 5-epimerase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane;
Biological process	heparan sulfate proteoglycan biosynthetic process; heparin biosynthetic process; glycosaminoglycan biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	26035
	93683
	ENSG00000138604
	ENSMUSG00000032252
	O94923
	Q9EPS3
	NM_015554; NM_001324091; NM_001324092; NM_001324093; NM_001324094
	NM_033320; NM_001368304
	NP_001311020; NP_001311021; NP_001311022; NP_001311023; NP_056369
	NP_201577; NP_001355233
	Wikidata
View/Edit Human	View/Edit Mouse

D-glucuronyl C5-epimerase is an enzyme that in humans is encoded by the GLCE gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138604 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032252 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ghiselli G, Agrawal A (Aug 2005). "The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the β-catenin–TCF4 pathway". Biochem J. 390 (Pt 2): 493–9. doi:10.1042/BJ20050152. PMC 1198929. PMID 15853773.
^ "Entrez Gene: GLCE glucuronic acid epimerase".

Grigorieva E, Eshchenko T, Rykova VI, et al. (2008). "Decreased expression of human D-glucuronyl C5-epimerase in breast cancer". Int. J. Cancer. 122 (5): 1172–6. doi:10.1002/ijc.23203. PMID 17985344.
Hagner-McWhirter A, Li JP, Oscarson S, Lindahl U (2004). "Irreversible glucuronyl C5-epimerization in the biosynthesis of heparan sulfate". J. Biol. Chem. 279 (15): 14631–8. doi:10.1074/jbc.M313760200. PMID 14718527.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Crawford BE, Olson SK, Esko JD, Pinhal MA (2001). "Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase". J. Biol. Chem. 276 (24): 21538–43. doi:10.1074/jbc.M100880200. PMID 11279150.
Li JP, Gong F, El Darwish K, et al. (2001). "Characterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate". J. Biol. Chem. 276 (23): 20069–77. doi:10.1074/jbc.M011783200. PMID 11274177.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138604 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032252 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15853773-5] Ghiselli G, Agrawal A (Aug 2005). "The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the β-catenin–TCF4 pathway". Biochem J. 390 (Pt 2): 493–9. doi:10.1042/BJ20050152. PMC 1198929. PMID 15853773.

[entrez-6] "Entrez Gene: GLCE glucuronic acid epimerase".

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References

Further reading