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English: Model of the replicase-transcriptase complex of a coronavirus. Illustration shows how the RNA sliding clamp for processivity and primase domain for priming (nsp7 and nsp8 – green/orange) could assemble on viral dsRNA and interact with the putative multi-subunit coronavirus polymerase complex consisting of RdRp for replication (nsp12 – red), ExoN for proofreading (nsp14 – dark blue), and ExoN cofactor (nsp10 – yellow). To initiate replication-transcription there is a short (∼6 n.t.) primer generated by the non-canonical RdRp activity of nsp8 (I and II). Binding of ssRNA by RNA binding proteins (nsp9 – light blue) to avoid secondary structure is also shown. A helicase to unwind RNA (nsp13) is not shown downstream.
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This file is a derivative work of an image by Everett Clinton Smith and Mark R. Denison

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003760
Author Guest2625
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Replication-transcription complex for Coronaviruses cropped

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17 May 2020

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Date/TimeThumbnailDimensionsUserComment
current05:37, 18 May 2020Thumbnail for version as of 05:37, 18 May 20201,387 × 695 (170 KB)Guest2625less bright colors
03:01, 18 May 2020Thumbnail for version as of 03:01, 18 May 20201,387 × 695 (150 KB)Guest2625Uploaded own work with UploadWizard

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