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Summary
DescriptionIgG.Opsonization.png
English: The variable, or Fab, region of the antibody binds with high specificity to an epitope on an antigen. This opsonizes the antigen for phagocytic cells: the FcR binds the Fc region of the antibody, facilitating phagocytosis. FcRs are also present on NK Cells, which are important for clearing tumor cells and virally-infected cells.
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IgG binds antigen with high affinity via the Fab region; the Fc region is then bound by Fc Receptor (FcR) on phagocytic or NK cells - antibody-mediated opsonization.