DescriptionExperimental evidence of the dorsal lip as the neural inducer and genetic mechanisms..jpg
English: Figure 1: Mangold's dorsal lip transplant experiment in Xenopus demonstrated that a transplanted dorsal lip could induce the formation of a double axis in the new host embryo, solidifying the dorsal lip's sufficiency in neural induction (A). Injection of extracted mRNA from the dorsal lip into irradiated Xenopus embryos rescued neural induction and overall development demonstrating there is a genetic basis of neural induction (B). Establishment of cDNA libraries from extracted dorsal lip mRNA identified candidate genes that may be responsible for neural induction. One such candidate gene, noggin, is sufficient for rescuing development of irradiated embryos when its mRNA is injected (C).
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