File:5tdi cathepsinK odanacatib.png
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Summary
| Description |
The X-ray crystallography structure of human cathepsin K in complex with the covalent inhibitor odanacatib, shown in light blue with covalently modified catalytic cysteine in green. Odanacatib was studied in clinical trials as a cathepsin K inhibitor for osteoporosis. Rendered with PyMol from PDB: 5TDI. Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib. Law, S., Andrault, P.M., Aguda, A.H., Nguyen, N.T., Kruglyak, N., Brayer, G.D., Bromme, D. (2017) Biochem J 474: 851-864 PubMed: 28049758 DOI: 10.1042/BCJ20160985 |
| Date | 27 Deecember 2021 |
| Source | Own work |
| Author | Opabinia regalis |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 06:35, 28 December 2021 | | 800 × 600 (266 KB) | Opabinia regalis | {{Information |Description=The X-ray crystallography structure of human cathepsin K in complex with the covalent inhibitor odanacatib, shown in light blue with covalently modified catalytic cysteine in green. Odanacatib was studied in clinical trials as a cathepsin K inhibitor for osteoporosis. Rendered with PyMol from {{PDB|5TDI}}. Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib. Law, S., Andrault, P.M., Aguda, A.H., Nguyen, N.T., Kruglyak, N.... |
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