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English: Critical quality attributes (CQAs) that dictate the performance of the mRNA construct to express the gene of interest efficiently. Five principal CQAs include 5′ capping efficiency and structure; UTR structure, length, and regulatory elements; modification of coding sequence; poly-A-tail properties; mRNA purity.
Date
Source Jackson, N.A.C., Kester, K.E., Casimiro, D. et al. The promise of mRNA vaccines: a biotech and industrial perspective. npj Vaccines 5, 11 (2020). https://doi.org/10.1038/s41541-020-0159-8
Author Nicholas A. C. Jackson, Kent E. Kester, Danilo Casimiro, Sanjay Gurunathan, and Frank DeRosa

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Critical quality attributes (CQAs) that dictate the performance of the mRNA construct to express the gene of interest efficiently.

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4 February 2020

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current08:16, 12 September 2021Thumbnail for version as of 08:16, 12 September 20211,895 × 1,103 (111 KB)Guest2625Uploaded a work by Nicholas A. C. Jackson, Kent E. Kester, Danilo Casimiro, Sanjay Gurunathan, and Frank DeRosa from Jackson, N.A.C., Kester, K.E., Casimiro, D. et al. The promise of mRNA vaccines: a biotech and industrial perspective. npj Vaccines 5, 11 (2020). https://doi.org/10.1038/s41541-020-0159-8 with UploadWizard

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