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FGL1

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FGL1
Identifiers
AliasesFGL1, HFREP1, HP-041, LFIRE-1, LFIRE1, fibrinogen like 1, HPS
External IDsOMIM: 605776; MGI: 102795; HomoloGene: 37927; GeneCards: FGL1; OMA:FGL1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_201553
NM_004467
NM_147203
NM_201552

NM_145594

RefSeq (protein)

NP_004458
NP_671736
NP_963846
NP_963847

NP_663569

Location (UCSC)Chr 8: 17.86 – 17.91 MbChr 8: 41.64 – 41.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. In humans, FGL-1 is encoded by the FGL1 gene.[5][6] It is classified as a hepatokine. Four splice variants exist for this gene.

Function

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Fibrinogen-like protein 1 is a member of the fibrinogen family of proteins, which also includes fibrinogen, fibrinogen-like protein 2, and clotting factors V, VIII, and XIII. FGL-1 is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of that are common to all members of the fibrinogen family. However, FGL-1 lacks the platelet-binding site, cross-linking region, and thrombin-sensitive site which allow the other members of the fibrinogen family to aid in fibrin clot formation.[6]

FGL-1 has also been observed to strongly bind to and activate LAG-3, a regulatory protein expressed on T cells. As LAG-3 has an important role in controlling activated T cells, manipulating FGL-1 binding to T cells has been proposed for both cancer immunotherapy and anti-inflammatory treatments.[7]

Clinical significance

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FGL-1 may play a role in the development of hepatocellular carcinomas.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104760Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031594Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yamamoto T, Gotoh M, Sasaki H, Terada M, Kitajima M, Hirohashi S (Jul 1993). "Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1". Biochem Biophys Res Commun. 193 (2): 681–7. doi:10.1006/bbrc.1993.1678. PMID 8390249.
  6. ^ a b c "Entrez Gene: FGL1 fibrinogen-like 1".
  7. ^ Wang J, Sanmamed MF, Datar I, Su TT, Ji L, Sun J, et al. (January 2019). "Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3". Cell. 176 (1–2): 334–347.e12. doi:10.1016/j.cell.2018.11.010. PMC 6365968. PMID 30580966.

Further reading

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