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Benzthiazide

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Benzthiazide
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability60 to 70%
Protein binding30%
Elimination half-life5 to 15 hours
ExcretionRenal
Identifiers
  • 6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)- 4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.001.874 Edit this at Wikidata
Chemical and physical data
FormulaC15H14ClN3O4S3
Molar mass431.92 g·mol−1
3D model (JSmol)
  • O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)/N=C(\N2)CSCc3ccccc3)N
  • InChI=1S/C15H14ClN3O4S3/c16-11-6-12-14(7-13(11)25(17,20)21)26(22,23)19-15(18-12)9-24-8-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,18,19)(H2,17,20,21) checkY
  • Key:NDTSRXAMMQDVSW-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Benzthiazide (BAN/INN, also known as benzothiazide; trade names Aquatag, Dihydrex, Diucen, Edemax, Exna, Foven and others[1]) is a thiazide diuretic used in the treatment of high blood pressure and edema. It is no longer available in the United States.

In the United Kingdom, it was also sold in combination with the potassium-sparing diuretic triamterene under the trade name Dytide.[2] The same combination is still available in Switzerland as Dyrenium compositum.[3]

References

[edit]
  1. ^ Triggle DJ, Ganellin CR, MacDonald F (1996). Dictionary of Pharmacological Agents. Vol. 1. Boca Raton: Chapman & Hall/CRC. p. 246. ISBN 0-412-46630-9. Retrieved on August 29, 2008 through Google Book Search.
  2. ^ "Triamterene and Benzthiazide". PatientUK. 2005. Retrieved 2008-08-29.
  3. ^ "Dyrenium compositum". Doetsch Grether. n.d. Archived from the original on February 11, 2007. Retrieved 2008-08-29.