Sodium calcium edetate

Sodium calcium edetate
Clinical data
Trade names	Calcium disodium versenate, others
Other names	calcium disodium EDTA, edetate calcium disodium, sodium calcium edetate
AHFS/Drugs.com	Monograph
Routes of; administration	IV, IM
Drug class	chelating agent
ATC code	V03AB03 (WHO) ;
Legal status
Legal status	US: WARNING;
Identifiers
	IUPAC name Calcium disodium 2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate;
CAS Number	62-33-9;
PubChem CID	6093170;
DrugBank	DB00974;
ChemSpider	5883;
UNII	8U5D034955;
ChEBI	CHEBI:4757;
E number	E385 (antioxidants, ...)
CompTox Dashboard (EPA)	DTXSID2036409 ;
ECHA InfoCard	100.000.482
Chemical and physical data
Formula	C10H12CaN2Na2O8
Molar mass	374.270 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C(CN(CC(=O)[O-])CC(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Ca+2];
	InChI InChI=1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4; Key:SHWNNYZBHZIQQV-UHFFFAOYSA-J;

Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning,^[2] including both short-term and long-term lead poisoning.^[3] Sodium calcium edetate came into medical use in the United States in 1953.^[3]

Chelation agent

Sodium calcium edetate is in the chelating agent family of medication.^[3] It is a salt of edetate with two sodium atoms and one calcium atom.^[4] It works by binding to a number of heavy metals, which renders them almost inert and allows them to leave the body in the urine.^[3]

Edetate disodium (Endrate) is a different formulation which does not have the same effects.^[3]

Medical use

Sodium calcium edetate's primary use is to treat lead poisoning,^[2] for which it is an alternative to succimer.^[3] It is given by slow injection into a vein or into a muscle.^[2]

For lead encephalopathy sodium calcium edetate is typically used together with dimercaprol.^[3] It may also be used to treat plutonium poisoning.^[5] It does not appear to be useful for poisoning by tetra-ethyl lead.^[3]

Side effects

Common side effects include pain at the site of injection.^[3] Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure.^[2] Benefits when needed in pregnancy are likely greater than the risks.^[3]

History

Sodium calcium edetate came into medical use in the United States in 1953.^[3] It is on the World Health Organization's List of Essential Medicines.^[6]

References

^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^ ^a ^b ^c ^d Stuart MC, Kouimtzi M, Hill SR, eds. (2009). WHO Model Formulary 2008. World Health Organization. pp. 59, 62, 65. hdl:10665/44053. ISBN 9789241547659.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Edetate Calcium Disodium". The American Society of Health-System Pharmacists. Archived from the original on 16 January 2017. Retrieved 8 January 2017.
^ Kasture AV (2008). Pharmaceutical Chemistry. Vol. I. Pragati Books Pvt. Ltd. p. 16.11. ISBN 9788185790121. Archived from the original on 16 January 2017.
^ Flanagan R, Jones A, Maynard RL (2003). Antidotes: Principles and Clinical Applications. CRC Press. p. 47. ISBN 9780203485071. Archived from the original on 16 January 2017.
^ Organization WH (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva,CH: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

[FDA-AllBoxedWarnings-1] "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.

[WHO2008-2] Stuart MC, Kouimtzi M, Hill SR, eds. (2009). WHO Model Formulary 2008. World Health Organization. pp. 59, 62, 65. hdl:10665/44053. ISBN 9789241547659.

[AHFS2017-3] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Edetate Calcium Disodium". The American Society of Health-System Pharmacists. Archived from the original on 16 January 2017. Retrieved 8 January 2017.

[4] Kasture AV (2008). Pharmaceutical Chemistry. Vol. I. Pragati Books Pvt. Ltd. p. 16.11. ISBN 9788185790121. Archived from the original on 16 January 2017.

[5] Flanagan R, Jones A, Maynard RL (2003). Antidotes: Principles and Clinical Applications. CRC Press. p. 47. ISBN 9780203485071. Archived from the original on 16 January 2017.

[WHO21st-6] Organization WH (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva,CH: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

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