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Protein-coding gene in the species Homo sapiens
Transmembrane channel-like protein 6 is a protein that in humans is encoded by the TMC6 gene .[ 5] [ 6] In vivo , TMC6 and its homolog TMC8 , interact and form a complex with the zinc transporter 1 (SLC30A1 ) and localize mostly to the endoplasmic reticulum , but also to the nuclear membrane and Golgi apparatus .[ 7]
Inactivating mutations in TMC6 or TMC8 have been implicated as the genetic cause of the rare skin disorder epidermodysplasia verruciformis ,[ 7] human papillomaviruses (HPVs) of the skin resulting in the growth of scaly macules and papules , particularly on the hands and feet.
^ a b c GRCh38: Ensembl release 89: ENSG00000141524 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025572 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Ramoz N, Rueda LA, Bouadjar B, Montoya LS, Orth G, Favre M (Nov 2002). "Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis". Nat Genet . 32 (4): 579–81. doi :10.1038/ng1044 . PMID 12426567 . S2CID 20013445 . ^ "Entrez Gene: TMC6 transmembrane channel-like 6" .^ a b Lazarczyk, M; C Pons; JA Mendoza; P Cassonnet; Y Jacob; M Favre (2008-01-21). "Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses" . The Journal of Experimental Medicine . 205 (1): 35–42. doi :10.1084/jem.20071311 . PMC 2234378 PMID 18158319 .
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