EHD2

EHD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QPT, 4CID
Identifiers
Aliases	EHD2, PAST2, EH domain containing 2
External IDs	OMIM: 605890; MGI: 2154274; HomoloGene: 22825; GeneCards: EHD2; OMA:EHD2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.33 Start 47,713,422 bp End 47,743,134 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 A2|7 8.65 cM Start 15,680,883 bp End 15,701,492 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right coronary artery popliteal artery tibial arteries subcutaneous adipose tissue left coronary artery Descending thoracic aorta ascending aorta right lung canal of the cervix Top expressed in ascending aorta aortic valve brown adipose tissue left lung right lung left lung lobe right lung lobe ankle subcutaneous adipose tissue white adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding protein domain specific binding nucleotide binding calcium ion binding GTP binding hydrolase activity ATP binding nucleic acid binding identical protein binding Cellular component caveola endosome membrane recycling endosome membrane cytoplasm cytosol nucleus membrane perinuclear region of cytoplasm endosome extrinsic component of membrane extracellular exosome plasma membrane microtubule cytoskeleton intercellular bridge Biological process blood coagulation endocytosis protein localization to plasma membrane plasma membrane tubulation positive regulation of myoblast fusion positive regulation of endocytic recycling actin cytoskeleton organization cortical actin cytoskeleton organization endocytic recycling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30846 259300 Ensembl ENSG00000024422 ENSMUSG00000074364 UniProt Q9NZN4 Q8BH64 RefSeq (mRNA) NM_014601 NM_153068 RefSeq (protein) NP_055416 NP_694708 Location (UCSC) Chr 19: 47.71 – 47.74 Mb Chr 7: 15.68 – 15.7 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

EH-domain containing 2, also known as EHD2, is a human gene belonging to the EHD protein family.

Further reading

• Pohl U, Smith JS, Tachibana I, et al. (2000). "EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins". Genomics. 63 (2): 255–62. doi:10.1006/geno.1999.6087. PMID 10673336.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Guilherme A, Soriano NA, Bose S, et al. (2004). "EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton". J. Biol. Chem. 279 (11): 10593–605. doi:10.1074/jbc.M307702200. PMID 14676205.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Park SY, Ha BG, Choi GH, et al. (2004). "EHD2 interacts with the insulin-responsive glucose transporter (GLUT4) in rat adipocytes and may participate in insulin-induced GLUT4 recruitment". Biochemistry. 43 (23): 7552–62. doi:10.1021/bi049970f. PMID 15182197.
• Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMC 1134064. PMID 15242332.
• Guilherme A, Soriano NA, Furcinitti PS, Czech MP (2004). "Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes". J. Biol. Chem. 279 (38): 40062–75. doi:10.1074/jbc.M401918200. PMID 15247266.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

• Overview of all the structural information available in the PDB for UniProt: Q8BH64 (Mouse EH domain-containing protein 2 (EHD2)) at the PDBe-KB.