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Pierre Gönczy

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Full Professor
Pierre Gönczy
Pierre Gönczy in his laboratory in 2020
Born1962 (age 61–62)
Winterthur, Switzerland
CitizenshipSwitzerland
Academic background
Alma materUniversity of Geneva
Academic work
DisciplineBiology
Sub-disciplineCell biology
Developmental biology
InstitutionsÉcole Polytechnique Fédérale de Lausanne (EPFL)
Main interestsCentriole assembly and function
Asymmetric cell division
Websitehttps://www.epfl.ch/labs/gonczy-lab/

Pierre Gönczy (born 1962 in Winterthur, Switzerland) is a Swiss and Italian cell and developmental biologist. His research focuses on centriole biology and asymmetric cell division. He is currently professor at École Polytechnique Fédérale de Lausanne (EPFL),[1] where he directs the Laboratory of Cell and Developmental Biology.[2]

Career

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Gönczy studied biology at University of Geneva and graduated in 1987 with a diploma thesis in molecular immunology at the Department of Microbiology at University of Geneva.[3] In 1995, he received a PhD for his work on developmental biology and molecular genetics from the Rockefeller University, New York City, United States.[4][5][6] From 1996 to 2000 Gönczy joined the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany as a postdoctoral research fellow with Anthony Hyman to work on cell biology, cell division, and early embryonic development.[7] In 2000, he became Junior Group leader at Swiss Institute for Experimental Cancer Research (ISREC) in Lausanne, Switzerland. In 2005, he was first nominated Associate Professor, and since 2009 has been a Full Professor at École Polytechnique Fédérale de Lausanne (EPFL).[1]

Research

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Gönczy's research is in the realm of cell and developmental biology, focused mainly on the questions of centriole assembly and function, as well as asymmetric cell division.[8][9] His laboratory employs notably the model organism C. elegans and human cell lines in their research. The methods they use include functional genomics, cell biology, live imaging, super-resolution microscopy, biophysical analysis, and electron cryotomography.[10][11][12] He spearheaded the first ever functional genomic screening of a metazoan organism, leading to the systematic discovery of the function of the compendium of genes needed to build an embryo.[7]

Distinctions

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Gönczy is recipient of the EMBO Young Investigator Program Award (2000).[13] In 2005, he was elected an EMBO member.[1][14] He was co-founder of the startup company Cenix Bioscience.[15] He was a Whitman Fellow at the Marine Biology Laboratory, Woods Hole, USA in 2015, 2017, and 2018.[16][17][18]

Select publications

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  • Gönczy, Pierre; Echeverri, Christophe; Oegema, Karen; Coulson, Alan; Jones, Steven J. M.; Copley, Richard R.; Duperon, John; Oegema, Jeff; Brehm, Michael; Cassin, Etienne; Hannak, Eva; Kirkham, Matthew; Pichler, Silke; Flohrs, Kathrin; Goessen, Anoesjka; Leidel, Sebastian; Alleaume, Anne-Marie; Martin, Cécilie; Özlü, Nurhan; Bork, Peer; Hyman, Anthony A. (2000). "Functional genomic analysis of cell division in C. Elegans using RNAi of genes on chromosome III". Nature. 408 (6810): 331–336. Bibcode:2000Natur.408..331G. doi:10.1038/35042526. PMID 11099034. S2CID 4364278.
  • Colombo, K.; Grill, Stephan W.; Kimple, Randall J.; Willard, Francis S.; Siderovski, David P.; Gönczy, Pierre (2003). "Translation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos". Science. 300 (5627): 1957–1961. Bibcode:2003Sci...300.1957C. doi:10.1126/science.1084146. PMID 12750478. S2CID 46204090.
  • Leidel, Sebastian; Delattre, Marie; Cerutti, Lorenzo; Baumer, Karine; Gönczy, Pierre (2005). "SAS-6 defines a protein family required for centrosome duplication in C. Elegans and in human cells". Nature Cell Biology. 7 (2): 115–125. doi:10.1038/ncb1220. PMID 15665853. S2CID 4634352.
  • Kitagawa, Daiju; Vakonakis, Ioannis; Olieric, Natacha; Hilbert, Manuel; Keller, Debora; Olieric, Vincent; Bortfeld, Miriam; Erat, Michèle C.; Flückiger, Isabelle; Gönczy, Pierre; Steinmetz, Michel O. (2011). "Structural Basis of the 9-Fold Symmetry of Centrioles". Cell. 144 (3): 364–375. doi:10.1016/j.cell.2011.01.008. PMC 3089914. PMID 21277013.
  • Guichard, Paul; Hachet, Virginie; Majubu, Norbert; Neves, Aitana; Demurtas, Davide; Olieric, Natacha; Fluckiger, Isabelle; Yamada, Akinori; Kihara, Kumiko; Nishida, Yuichiro; Moriya, Shigeharu; Steinmetz, Michel O.; Hongoh, Yuichi; Gönczy, Pierre (2013). "Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetry". Current Biology. 23 (17): 1620–1628. doi:10.1016/j.cub.2013.06.061. PMID 23932403. S2CID 17329110.
  • Nievergelt, Adrian P.; Banterle, Niccolò; Andany, Santiago H.; Gönczy, Pierre; Fantner, Georg E. (2018). "High-speed photothermal off-resonance atomic force microscopy reveals assembly routes of centriolar scaffold protein SAS-6" (PDF). Nature Nanotechnology. 13 (8): 696–701. Bibcode:2018NatNa..13..696N. doi:10.1038/s41565-018-0149-4. PMID 29784964. S2CID 205567962.

References

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  1. ^ a b c "Pierre Gönczy". people.epfl.ch. Retrieved 2020-09-15.
  2. ^ "Gönczy Lab – Cell and Developmental Biology". www.epfl.ch. Retrieved 2020-09-15.
  3. ^ Gönczy, P; Reith, W; Barras, E; Lisowska-Grospierre, B; Griscelli, C; Hadam, M R; Mach, B (1989-01-01). "Inherited immunodeficiency with a defect in a major histocompatibility complex class II promoter-binding protein differs in the chromatin structure of the HLA-DRA gene". Molecular and Cellular Biology. 9 (1): 296–302. doi:10.1128/MCB.9.1.296. ISSN 0270-7306. PMC 362172. PMID 2467188.
  4. ^ Trelsman, Jessica; Gönczy, Pierre; Vashishtha, Malini; Harris, Esther; Desplan, Claude (1989-11-03). "A single amino acid can determine the DNA binding specificity of homeodomain proteins". Cell. 59 (3): 553–562. doi:10.1016/0092-8674(89)90038-X. PMID 2572327. S2CID 29300056.
  5. ^ Castrillon, D. H.; Gonczy, P.; Alexander, S.; Rawson, R.; Eberhart, C. G.; Viswanathan, S.; DiNardo, S.; Wasserman, S. A. (1993-10-01). "Toward a Molecular Genetic Analysis of Spermatogenesis in Drosophila Melanogaster: Characterization of Male-Sterile Mutants Generated by Single P Element Mutagenesis". Genetics. 135 (2): 489–505. doi:10.1093/genetics/135.2.489. ISSN 0016-6731. PMC 1205651. PMID 8244010.
  6. ^ Gonczy, P (1994-07-01). "roughex is a dose-dependent regulator of the second meiotic division during Drosophila spermatogenesis". Cell. 77 (7): 1015–1025. doi:10.1016/0092-8674(94)90441-3. PMID 8020092. S2CID 32059039.
  7. ^ a b Gönczy, Pierre; Echeverri, Christophe; Oegema, Karen; Coulson, Alan; Jones, Steven J. M.; Copley, Richard R.; Duperon, John; Oegema, Jeff; Brehm, Michael; Cassin, Etienne; Hannak, Eva (2000-11-16). "Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III". Nature. 408 (6810): 331–336. Bibcode:2000Natur.408..331G. doi:10.1038/35042526. ISSN 1476-4687. PMID 11099034. S2CID 4364278.
  8. ^ Kitagawa, Daiju; Vakonakis, Ioannis; Olieric, Natacha; Hilbert, Manuel; Keller, Debora; Olieric, Vincent; Bortfeld, Miriam; Erat, Michèle C.; Flückiger, Isabelle; Gönczy, Pierre; Steinmetz, Michel O. (2011-02-04). "Structural Basis of the 9-Fold Symmetry of Centrioles". Cell. 144 (3): 364–375. doi:10.1016/j.cell.2011.01.008. PMC 3089914. PMID 21277013.
  9. ^ Guichard, Paul; Hachet, Virginie; Majubu, Norbert; Neves, Aitana; Demurtas, Davide; Olieric, Natacha; Fluckiger, Isabelle; Yamada, Akinori; Kihara, Kumiko; Nishida, Yuichiro; Moriya, Shigeharu (2013-09-09). "Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetry". Current Biology. 23 (17): 1620–1628. doi:10.1016/j.cub.2013.06.061. PMID 23932403. S2CID 17329110.
  10. ^ Colombo, K. (2003-05-15). "Translation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos". Science. 300 (5627): 1957–1961. Bibcode:2003Sci...300.1957C. doi:10.1126/science.1084146. ISSN 0036-8075. PMID 12750478. S2CID 46204090.
  11. ^ Leidel, Sebastian; Delattre, Marie; Cerutti, Lorenzo; Baumer, Karine; Gönczy, Pierre (2005-02-23). "SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells". Nature Cell Biology. 7 (2): 115–125. doi:10.1038/ncb1220. ISSN 1465-7392. PMID 15665853. S2CID 4634352.
  12. ^ Nievergelt, Adrian P.; Banterle, Niccolò; Andany, Santiago H.; Gönczy, Pierre; Fantner, Georg E. (2018-08-21). "High-speed photothermal off-resonance atomic force microscopy reveals assembly routes of centriolar scaffold protein SAS-6". Nature Nanotechnology. 13 (8): 696–701. Bibcode:2018NatNa..13..696N. doi:10.1038/s41565-018-0149-4. ISSN 1748-3387. PMID 29784964. S2CID 205567962.
  13. ^ "Pierre Gönczy - Find an EMBO Young Investigator / EMBO Installation Grantee / EMBO Global Investigator". yip-search.embo.org. Retrieved 2020-09-15.
  14. ^ Katja. "Find a Member". EMBO. Retrieved 2020-09-15.
  15. ^ "Cenix Ends Worm Work with Screen Publication". GenomeWeb. May 2005. Retrieved 2020-09-15.
  16. ^ "2015 MBL Research Awardees". www.mbl.edu. Retrieved 2020-09-15.
  17. ^ "2017 Whitman Center Research Awardees". www.mbl.edu. Retrieved 2020-09-15.
  18. ^ "2018 Whitman Center Research Awardees". www.mbl.edu. Retrieved 2020-09-15.
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