Panayiota Poirazi
Panayiota Poirazi | |
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Born | Cyprus | August 6, 1974
Alma mater | University of Cyprus, Nicosia, Cyprus University of Southern California, Los Angeles, California, USA |
Known for | modelling dendritic computations |
Scientific career | |
Fields | Neuroscience, Computational Neuroscience |
Institutions | Foundation of Research and Technology-Hellas (FORTH), Institute of Molecular Biology and Biotechnology (IMBB) |
Thesis | Contributions of active dendrites and structural plasticity to the neural substrate for learning and memory (2000) |
Website | http://www.dendrites.gr/ |
Panayiota Poirazi is a neuroscientist known for her work in modelling dendritic computations. She is an elected member of the European Molecular Biology Organization (EMBO).
Education and career
[edit]Poirazi studied at the University of Cyprus from 1992 until 1996.[1] She earned an M.S. from the University of Southern California in 1998,[2] and went on to earn her Ph.D. from there in 2000.[3] Following her Ph.D., she worked at the Alexander Fleming Instite of Immunology in Greece until 2001, when she moved to the Foundation for Research and Technology-Hellas (FORTH) in Crete, Greece in 2004.[1] As of 2021, she is the director of research at the Institute of Molecular Biology and Biotechnology (IMBB) at the Foundation for Research and Technology-Hellas (FORTH).[1]
Research
[edit]Poirazi is known for her work in neurobiology where she focuses on dendrites, the portion of a neuron that propagates signals. Her early research generated predictive models of how active dendrites and structural plasticity enhance storage capacity in single neurons.[4] She has used biophysical models of pyramidal neurons to show that dendrites of these cells integrate inputs in a sigmoidal manner, enabling the neurons to act as two-layer neural network devices.[5][6] Poirazi has built a circuit-level model of the hippocampus that shows how memories are linked through time.[7] She has developed and applied biophysical models to explain how human neurons compute information, with a focus on solving the XOR problem.[8][9]
Selected publications
[edit]- Poirazi, Panayiota; Brannon, Terrence; Mel, Bartlett W. (March 2003). "Pyramidal Neuron as Two-Layer Neural Network". Neuron. 37 (6): 989–999. doi:10.1016/s0896-6273(03)00149-1. PMID 12670427. S2CID 1680778.
- Poirazi, Panayiota; Mel, Bartlett W. (March 2001). "Impact of Active Dendrites and Structural Plasticity on the Memory Capacity of Neural Tissue". Neuron. 29 (3): 779–796. doi:10.1016/s0896-6273(01)00252-5. PMID 11301036. S2CID 14303314.
- Zhou, Yu; Won, Jaejoon; Karlsson, Mikael Guzman; Zhou, Miou; Rogerson, Thomas; Balaji, Jayaprakash; Neve, Rachael; Poirazi, Panayiota; Silva, Alcino J (November 2009). "CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala". Nature Neuroscience. 12 (11): 1438–1443. doi:10.1038/nn.2405. PMC 2783698. PMID 19783993.
- Poirazi, Panayiota; Brannon, Terrence; Mel, Bartlett W. (March 2003). "Arithmetic of Subthreshold Synaptic Summation in a Model CA1 Pyramidal Cell". Neuron. 37 (6): 977–987. doi:10.1016/s0896-6273(03)00148-x. PMID 12670426. S2CID 15742277.
- Richards, Blake A.; Lillicrap, Timothy P.; Beaudoin, Philippe; Bengio, Yoshua; Bogacz, Rafal; Christensen, Amelia; Clopath, Claudia; Costa, Rui Ponte; de Berker, Archy; Ganguli, Surya; Gillon, Colleen J.; Hafner, Danijar; Kepecs, Adam; Kriegeskorte, Nikolaus; Latham, Peter; Lindsay, Grace W.; Miller, Kenneth D.; Naud, Richard; Pack, Christopher C.; Poirazi, Panayiota; Roelfsema, Pieter; Sacramento, João; Saxe, Andrew; Scellier, Benjamin; Schapiro, Anna C.; Senn, Walter; Wayne, Greg; Yamins, Daniel; Zenke, Friedemann; Zylberberg, Joel; Therien, Denis; Kording, Konrad P. (November 2019). "A deep learning framework for neuroscience". Nature Neuroscience. 22 (11): 1761–1770. doi:10.1038/s41593-019-0520-2. PMC 7115933. PMID 31659335.
Awards and honors
[edit]In 2017, Poirazi was elected a member of the European Molecular Biology Organization.[10] In 2018, she received a Friedrich Wilhelm Bessel Research Award from the Alexander von Humboldt Foundation.[11]
References
[edit]- ^ a b c "PANAYIOTA POIRAZI – FKNE". Retrieved 2021-12-31.
- ^ Poirazi, Panayiota (1998). Memory capacity of neurons with active dendrites (Thesis). OCLC 42188424.
- ^ Poirazi, Panayiota (2000). Contributions of active dendrites and structural plasticity to the neural substrate for learning and memory (Thesis). OCLC 51873663.
- ^ Poirazi, Panayiota; Mel, Bartlett W. (2001). "Impact of Active Dendrites and Structural Plasticity on the Memory Capacity of Neural Tissue". Neuron. 29 (3): 779–796. doi:10.1016/S0896-6273(01)00252-5. PMID 11301036. S2CID 14303314.
- ^ Poirazi, Panayiota; Brannon, Terrence; Mel, Bartlett W. (March 2003). "Pyramidal Neuron as Two-Layer Neural Network". Neuron. 37 (6): 989–999. doi:10.1016/s0896-6273(03)00149-1. PMID 12670427. S2CID 1680778.
- ^ Poirazi, Panayiota; Brannon, Terrence; Mel, Bartlett W. (2003-03-27). "Arithmetic of Subthreshold Synaptic Summation in a Model CA1 Pyramidal Cell". Neuron. 37 (6): 977–987. doi:10.1016/S0896-6273(03)00148-X. ISSN 0896-6273. PMID 12670426. S2CID 15742277.
- ^ Kastellakis, George; Silva, Alcino J.; Poirazi, Panayiota (2016-11-01). "Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites". Cell Reports. 17 (6): 1491–1504. doi:10.1016/j.celrep.2016.10.015. ISSN 2211-1247. PMC 5149530. PMID 27806290.
- ^ Gidon, Albert; Zolnik, Timothy Adam; Fidzinski, Pawel; Bolduan, Felix; Papoutsi, Athanasia; Poirazi, Panayiota; Holtkamp, Martin; Vida, Imre; Larkum, Matthew Evan (2020-01-03). "Dendritic action potentials and computation in human layer 2/3 cortical neurons". Science. 367 (6473): 83–87. Bibcode:2020Sci...367...83G. doi:10.1126/science.aax6239. PMID 31896716. S2CID 209676937.
- ^ Cepelewicz, Jordana (2020-01-14). "Hidden Computational Power Found in the Arms of Neurons". Quanta Magazine. Retrieved 2021-12-31.
- ^ "IMBB-FORTH's Researcher Panayiota Poirazi elected as member of EMBO". Foundation for Research and Technology - Hellas. June 16, 2017. Retrieved 2021-12-31.
- ^ "Friedrich Wilhelm Bessel Research Award to IMBB researcher Panayiota Poirazi" (PDF). December 18, 2018. Retrieved December 31, 2021.
External links
[edit]- Panayiota Poirazi publications indexed by Google Scholar