Edward Wild (neuroscientist)
Prof Edward John Wild | |
---|---|
![]() Edward Wild in May 2023 | |
Born | UK |
Nationality | British |
Alma mater | Christ's College, Cambridge (1996–2001) University College London (2005–2008) |
Known for | Huntington's disease research and outreach |
Awards | Huntington's Disease Society of America Researcher of the Year, 2014; Huntington Society of Canada Community Leadership Award, 2013; Huntington Study Group Insight of the Year, 2015. |
Scientific career | |
Fields | Neuroscience |
Institutions | UCL Institute of Neurology; National Hospital for Neurology and Neurosurgery |
Thesis | Identification and evaluation of biomarkers for Huntington's disease (2009) |
Doctoral advisor | Sarah Tabrizi |
Website | edwild |
Edward Wild, also known as Ed Wild, is a British neurologist and neuroscientist in the field of Huntington's disease and an advocate for scientific outreach to the public.[1] He co-founded the Huntington's research news platform HDBuzz in 2010.[2] He is a professor of neurology at UCL Institute of Neurology and is an associate director of the UCL Huntington's Disease Centre.[3] He is also a consultant neurologist at the National Hospital for Neurology and Neurosurgery in London.[4]
Career
[edit]Wild studied medicine at Christ's College, Cambridge.[5] In his early career, he studied and published on the neurological phenomenon of déjà vu.[6] He undertook a PhD, supervised by professor Sarah Tabrizi, at the UCL Institute of Neurology, Queen Square, London,[7] during which he published research on biomarkers for Huntington's disease using magnetic resonance imaging measures of brain atrophy[8][9][10][11] and biochemical analysis of blood.[12][13] Wild and Tabrizi continue to work together at the UCL Huntington's Disease Centre.[14]
Wild and colleagues described a novel pathogenic pathway of immune activation in Huntington's[15][16] which later became the basis of clinical trials of immune-targeted therapies.[17] In 2015, he published the first successful detection and quantification of mutant huntingtin protein (the known cause of Huntington's) in human cerebrospinal fluid, using a novel 'single-molecule counting' immunoassay. This finding was noted as a 'research highlight' by Nature Reviews Neurology and won Wild the Huntington Study group 'Insight of the Year' award in 2015.[18][19][20] He has also published novel genetic causes of 'phenocopy' syndromes that mimic Huntington's disease.[21][22]
Wild's research since 2017 has focused on the potential of neurofilament light and mutant huntingtin protein[23][24] as biomarkers for Huntington's disease onset and progression. His work has shown that NFL has better prognostic value in Huntington's disease, but that mutant huntingtin might be a valuable marker for early and sensitive detection of change in clinical huntingtin-lowering trials.[25][24] He was a senior investigator in the clinical programme studying the antisense oligonucleotide tominersen to lower mutant huntingtin production in HD,[26] and gave the first dose of the drug to a patient in 2015.[27][28][29]
He serves on the Medical Advisory Panel of the UK Huntington's Disease Association,[2] the Editorial Board of the Journal of Huntington's Disease,[30] the Association of British Neurologists Neurogenetics Advisory Panel,[31] and the Translational Neurology Panel of the European Academy of Neurology.[32] He is a member of the Executive Committee of the European Huntington's Disease Network[33] and Co-lead facilitator of the Network’s Biomarkers Working Group.[34] He is a founder member of the advisory panel to the UK All-Party Parliamentary Group on Huntington's disease.[35][36]
He was promoted to professor of neurology in October 2020, in the UCL Faculty of Brain Sciences.[37] As of September 2022, Wild has authored 7 book chapters[3] and 150 peer-reviewed publications with over 12,000 citations.[38]
Public engagement work
[edit]In 2010, with Jeff Carroll, Wild founded HDBuzz, an online source of accessible news about Huntington's disease research,[39][40] that has received awards from patient advocacy groups.[41] He said he helped establish HDBuzz to provide tempered research news to counter the hype of medical press releases about HD.[42] He has commented that common online opinions that people with Huntington's disease should not be allowed to have children "borders on historical eugenics-type thinking".[43] He has described Huntington's as "the most curable incurable brain disorder" because of the possibility of targeting treatments to its known genetic cause.[44][45]
Wild appeared in the documentary feature film The Inheritance[46][47] and was a judge for the 2015 British Library / Europe PubMed Central 'Access to Understanding' contest for science writers.[48] He has appeared on the BBC Radio Naked Scientists programme.[49] In July 2016, he appeared on BBC Radio 4's Woman's Hour programme talking about Huntington's disease with Jenni Murray.[50] In December 2017, he appeared on RTE Radio 1 talking about Huntington's disease treatments.[51] In 2020, he appeared in the Ken Burns PBS documentary The Gene: An Intimate History.[52][53]
In 2021, he wrote the afterword of Patient 1,[54] a book by Charlotte Raven about her experiences with Huntington's disease, including her participation on the trial of the experimental drug tominersen.[29] Wild is Raven's doctor and injected her with the first dose of tominersen on the Gen-Peak trial.[29]
Personal life
[edit]Wild lives in East London with his partner Joel. They have a cat and a chihuahua, Riley.[29]
Awards and honours
[edit]- 2012 Huntington Society of Canada Community Leadership Award[55]
- 2014 Huntington's Disease Society of America Researcher of the Year Award.[56]
- 2015 Huntington Study Group Insight of the Year (for his CSF mutant huntingtin research).[20]
- 2017 Huntington Study Group Insight of the Year (for the finding that neurofilament light in blood can predict onset and progression of HD).[57]
- 2018 Elected Fellow of the Royal College of Physicians.[3]
References
[edit]- ^ Yohrling GJ, Vetter LA (2017). "Stewarding Hope: The Evolving Landscape of Huntington's Disease Science Communications". J Huntingtons Dis. 6 (1): 33–35. doi:10.3233/JHD-160230. PMID 28128771.
- ^ a b "HD Centre - People - Team Wild". UCL Queen Square Institute of Neurology. 17 October 2019. Retrieved 2 December 2021.
- ^ a b c "UCL Iris Profile – Prof. Edward Wild". Retrieved 2 December 2021.
- ^ Hayden, Erika (23 February 2016). "Should you edit your children's genes?". Nature. 530 (7591): 402–405. Bibcode:2016Natur.530..402C. doi:10.1038/530402a. PMID 26911764.
- ^ "Christ's College Pieces Magazine". 27 July 2021.
- ^ Phillips, Helen (25 March 2009). "Déjà vu: Where fact meets fantasy". New Scientist. pp. 3, 5. Archived from the original on 13 April 2016. Retrieved 31 March 2016.
{{cite web}}
: CS1 maint: bot: original URL status unknown (link) - ^ Wild, Edward (June 2009). Identification and evaluation of biomarkers for Huntington's disease (PhD Thesis). UCL Discovery Institutional Document Repository (Doctoral). University College London.
- ^ Dorsey, E. Ray; Beck, Christopher A.; Darwin, Kristin; Nichols, Paige; Brocht, Alicia F. D.; Biglan, Kevin M.; Shoulson, Ira; for the Huntington Study Group COHORT Investigators (2013-12-01). "Natural History of Huntington Disease". JAMA Neurology. 70 (12): 1520–1530. doi:10.1001/jamaneurol.2013.4408. ISSN 2168-6149. PMID 24126537.
- ^ Wild, Edward J.; Henley, Susie M. D.; Hobbs, Nicola Z.; Frost, Chris; MacManus, David G.; Barker, Roger A.; Fox, Nick C.; Tabrizi, Sarah J. (2010-05-15). "Rate and acceleration of whole-brain atrophy in premanifest and early Huntington's disease". Movement Disorders. 25 (7): 888–895. doi:10.1002/mds.22969. ISSN 1531-8257. PMC 9136537. PMID 20461806. S2CID 33524701.
- ^ Henley, Susie M. D.; Wild, Edward J.; Hobbs, Nicola Z.; Frost, Chris; MacManus, David G.; Barker, Roger A.; Fox, Nick C.; Tabrizi, Sarah J. (2009-04-30). "Whole-brain atrophy as a measure of progression in premanifest and early Huntington's disease". Movement Disorders. 24 (6): 932–936. doi:10.1002/mds.22485. ISSN 1531-8257. PMID 19243073. S2CID 206239857.
- ^ Wild, Edward; Hobbs, Nicola; Henley, Susie (2011). "Huntington's Disease and Dementia". Neuroimaging in Dementia. Springer-Verlag. ISBN 978-3642008177.
- ^ Wild, Edward J.; Tabrizi, Sarah J. (2008-01-01). "Biomarkers for Huntington's disease". Expert Opinion on Medical Diagnostics. 2 (1): 47–62. doi:10.1517/17530059.2.1.47. ISSN 1753-0059. PMID 23485116.
- ^ Weiss, Andreas; Träger, Ulrike; Wild, Edward J.; Grueninger, Stephan; Farmer, Ruth; Landles, Christian; Scahill, Rachael I.; Lahiri, Nayana; Haider, Salman (2012-10-01). "Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression". The Journal of Clinical Investigation. 122 (10): 3731–3736. doi:10.1172/JCI64565. ISSN 1558-8238. PMC 3461928. PMID 22996692.
- ^ Tabrizi, Sarah J.; Flower, Michael D.; Ross, Christopher A.; Wild, Edward J. (October 2020). "Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities". Nature Reviews Neurology. 16 (10): 529–546. doi:10.1038/s41582-020-0389-4. PMID 32796930. S2CID 221129777.
- ^ Björkqvist, M; Wild, EJ; Thiele, J; Silvestroni, A; Andre, R; Lahiri, N; Raibon, E; Lee, RV; Benn, CL; Soulet, D; Magnusson, A; Woodman, B; Landles, C; Pouladi, MA; Hayden, MR; Khalili-Shirazi, A; Lowdell, MW; Brundin, P; Bates, GP; Leavitt, BR; Möller, T; Tabrizi, SJ (4 August 2008). "A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease". The Journal of Experimental Medicine. 205 (8): 1869–77. doi:10.1084/jem.20080178. PMC 2525598. PMID 18625748.
- ^ Dalrymple, A; Wild, EJ; Joubert, R; Sathasivam, K; Björkqvist, M; Petersén, A; Jackson, GS; Isaacs, JD; Kristiansen, M; Bates, GP; Leavitt, BR; Keir, G; Ward, M; Tabrizi, SJ (July 2007). "Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates". Journal of Proteome Research. 6 (7): 2833–40. doi:10.1021/pr0700753. PMID 17552550.
- ^ "A Clinical Study in Subjects With Huntington's Disease to Assess the Efficacy and Safety of Three Oral Doses of Laquinimod - Full Text View". ClinicalTrials.gov. Retrieved 2016-03-31.
- ^ Wild, EJ; Boggio, R; Langbehn, D; Robertson, N; Haider, S; Miller, JR; Zetterberg, H; Leavitt, BR; Kuhn, R; Tabrizi, SJ; Macdonald, D; Weiss, A (May 2015). "Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients". The Journal of Clinical Investigation. 125 (5): 1979–86. doi:10.1172/JCI80743. PMC 4463213. PMID 25844897.
- ^ Chase, Alex (21 April 2015). "Huntington disease: Cerebrospinal fluid and MRI biomarkers for prodromal HD". Nature Reviews Neurology. 11 (5): 245. doi:10.1038/nrneurol.2015.63. PMID 25896083. S2CID 38300571.
- ^ a b "Announcing HSG's 2015 Award Winners". Huntington Study Group. Archived from the original on 2021-11-26. Retrieved 2016-03-31.
- ^ Hensman Moss, DJ; Poulter, M; Beck, J; Hehir, J; Polke, JM; Campbell, T; Adamson, G; Mudanohwo, E; McColgan, P; Haworth, A; Wild, EJ; Sweeney, MG; Houlden, H; Mead, S; Tabrizi, SJ (28 January 2014). "C9orf72 expansions are the most common genetic cause of Huntington disease phenocopies". Neurology. 82 (4): 292–9. doi:10.1212/WNL.0000000000000061. PMC 3929197. PMID 24363131.
- ^ Wild, EJ; Mudanohwo, EE; Sweeney, MG; Schneider, SA; Beck, J; Bhatia, KP; Rossor, MN; Davis, MB; Tabrizi, SJ (15 April 2008). "Huntington's disease phenocopies are clinically and genetically heterogeneous". Movement Disorders. 23 (5): 716–20. doi:10.1002/mds.21915. PMID 18181206. S2CID 3086383.
- ^ "Huntington's disease trial test is 'major advance'". BBC News. 8 June 2017.
- ^ a b Byrne, Lauren M.; Rodrigues, Filipe B.; Johnson, Eileanor B.; Wijeratne, Peter A.; De Vita, Enrico; Alexander, Daniel C.; Palermo, Giuseppe; Czech, Christian; Schobel, Scott; Scahill, Rachael I.; Heslegrave, Amanda; Zetterberg, Henrik; Wild, Edward J. (12 September 2018). "Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington's disease". Science Translational Medicine. 10 (458): eaat7108. doi:10.1126/scitranslmed.aat7108. PMID 30209243. S2CID 206695500.
- ^ Rodrigues, Filipe B.; Byrne, Lauren M.; Tortelli, Rosanna; Johnson, Eileanoir B.; Wijeratne, Peter A.; Arridge, Marzena; De Vita, Enrico; Ghazaleh, Naghmeh; Houghton, Richard; Furby, Hannah; Alexander, Daniel C.; Tabrizi, Sarah J.; Schobel, Scott; Scahill, Rachael I.; Heslegrave, Amanda; Zetterberg, Henrik; Wild, Edward J. (16 December 2020). "Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington's disease". Science Translational Medicine. 12 (574): eabc2888. doi:10.1126/scitranslmed.abc2888. PMC 7611886. PMID 33328328.
- ^ Tabrizi, Sarah J.; Leavitt, Blair R.; Landwehrmeyer, G. Bernhard; Wild, Edward J.; Saft, Carsten; Barker, Roger A.; Blair, Nick F.; Craufurd, David; Priller, Josef; Rickards, Hugh; Rosser, Anne; Kordasiewicz, Holly B.; Czech, Christian; Swayze, Eric E.; Norris, Daniel A.; Baumann, Tiffany; Gerlach, Irene; Schobel, Scott A.; Paz, Erika; Smith, Anne V.; Bennett, C. Frank; Lane, Roger M. (13 June 2019). "Targeting Huntingtin Expression in Patients with Huntington's Disease". New England Journal of Medicine. 380 (24): 2307–2316. doi:10.1056/NEJMoa1900907. hdl:20.500.11820/7da73cfb-3c2d-4f2e-9b92-463a6c7ad4de. PMID 31059641. S2CID 146811503.
- ^ Whipple, Tom. "Huntington's breakthrough offers hope to thousands". The Times. Retrieved 2 December 2021.
- ^ Devlin, Hannah (11 December 2017). "Excitement as trial shows Huntington's drug could slow progress of disease". the Guardian. Retrieved 2 December 2021.
- ^ a b c d Louise, Carpenter (30 October 2021). "Charlotte Raven: Huntington's disease is 'a burden that is almost impossible to bear'". The Times. Retrieved 2 December 2021.
- ^ "Journal of Huntington's Disease". IOS Press. Retrieved 2016-03-31.
- ^ "Association of British Neurologists Annual Report 2020-21" (PDF). Association of British Neurologists. Retrieved 2 December 2021.
- ^ "Neuroscience/Translational neurology". European Academy of Neurology.
- ^ "EHDN Structure – European Huntington's Disease Network". ehdn.org. Retrieved 2022-10-19.
- ^ "Biomarkers Working Group – European Huntington's Disease Network". EHDN. Retrieved 2 December 2021.
- ^ Harrison, Jacqueline (December 2013). The 'hidden no more' mass lobby June 2010 - using oral histories and cultural representations to explore the concealment of Huntington's disease. (Masters Thesis). University of Huddersfield Repository (masters).
- ^ "Massive Underestimation In The Prevalence Of Huntington's Disease In The UK Population". Science 2.0. 27 August 2014. Retrieved 2016-03-31.
- ^ "Promotions 2019-20 - Professors". UCL Human Resources. 29 June 2020.
- ^ "Dr Edward J Wild". Google Scholar Citations. Retrieved 2 November 2021.
- ^ Macleod, Rhona; Tibben, Aad (20 March 2014). Huntington's Disease (4 ed.). Oxford University Press. p. 171. ISBN 978-0199370474.
- ^ Kenneally, Christine (2015). The Best Australian Science Writing. NewSouth. ISBN 9781742242231.
- ^ "2014 Science Communication Awards: The winning entries". AMRC - Association of Medical Research Charities. Archived from the original on 2014-05-02. Retrieved 2016-09-30.
- ^ Peter, Forbes (20 March 2018). "How close are we to a cure for Huntington's?". The Independent. Retrieved 2 December 2021.
- ^ Brewer, Kirstie (11 June 2021). "Huntington's disease won't stop me having a baby". BBC News.
- ^ "Researcher Hopeful, Sure of Future Cure for Huntington's Disease". Huntington's Disease News. BioNews Network. 22 July 2016.
- ^ Wild, Edward J. (May 2016). "Huntington's Disease: The Most Curable Incurable Brain Disorder?". eBioMedicine. 8: 3–4. doi:10.1016/j.ebiom.2016.05.023. PMC 4919568. PMID 27428401.
- ^ "Watch The Inheritance Online | Vimeo On Demand". Vimeo. Retrieved 2016-03-31.
- ^ "Edward Wild". IMDb. Retrieved 4 May 2016.
- ^ "Access to Understanding Science Writing Competition 2015" (PDF). Access to Understanding. Europe PubMed Central.
- ^ "Huntington's And Immunity - Dr Ed Wild, University College London". The Naked Scientists. 25 October 2009. Retrieved 2016-04-01.
- ^ "Listener Week. The Hayes Sisters; Huntington's Disease; Coping with the school holidays on a low income". Woman's Hour. BBC Radio 4. Retrieved 15 July 2016.
- ^ "Morning Ireland - Breakthrough made in efforts to counter Huntington's disease". RTE Radio. RTE. Retrieved 2 December 2021.
- ^ Burns, Ken. "The Gene - Part 1: Dawn of the Modern Age of Genetics - Episode 1". PBS. Retrieved 2 December 2021.
- ^ "Part 1: Dawn of the Modern Age of Genetics". Ken Burns Presents: The Gene. 7 April 2020. Retrieved 2 December 2021.
- ^ Raven, Charlotte; Wild, Edward (4 November 2021). Patient 1. Penguin.
- ^ "World-Renowned International Huntington Neurologists and Researchers to be featured at the Huntington Society of Canada's National Conference" (PDF). Huntington Society of Canada.
- ^ "Carroll receives HDSA Researcher of the Year award". Western Today. Retrieved 2016-03-31.
- ^ "UCL HD Centre wins two prestigious 'Insight of the Year' awards". UCL Queen Square Institute of Neurology. September 12, 2017.